Acta Neurochirurgica

, 151:1377

Association of F18-fluoro-ethyl-tyrosin uptake and 5-aminolevulinic acid-induced fluorescence in gliomas

Authors

    • Department of NeurosurgeryCharité Universitätsmedizin Berlin
  • Martin Misch
    • Department of NeurosurgeryCharité Universitätsmedizin Berlin
  • Peter Horn
    • Department of NeurosurgeryCharité Universitätsmedizin Berlin
  • Arend Koch
    • Department of NeuropathologyCharité Universitätsmedizin Berlin
  • Nyuyki Fonyuy
    • Department of Nuclear MedicineCharité Universitätsmedizin Berlin
  • Michail Plotkin
    • Department of Nuclear MedicineCharité Universitätsmedizin Berlin
Clinical Article

DOI: 10.1007/s00701-009-0462-7

Cite this article as:
Stockhammer, F., Misch, M., Horn, P. et al. Acta Neurochir (2009) 151: 1377. doi:10.1007/s00701-009-0462-7

Abstract

Purpose

Malignant gliomas are highly infiltrative tumours with a fatal prognosis. F18-fluoroethyl-tyrosine (FET)-positron emission tomography (PET) often reveals a broader extension of these tumours compared with contrast-enhanced magnetic resonance imaging (MRI). Complete resection of the contrast-enhancing lesion is aspired. Fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) improved the extent of resection. In this study, we investigated whether the FET uptake correlates with the extent of resection using 5-ALA-induced fluorescence.

Methods

Thirteen patients who underwent preoperative and postoperative MRI, FET-PET and fluorescence-guided neuronavigated resection were included in this study. The areas in which intraoperative fluorescence terminated the resection were marked. After fusion of PET and MRI, the standardized uptake value (SUV) of FET related to normal brain (SUVR) was measured in regions of interest corresponding to resected and remaining tissue, respectively. Receiver-operating characteristic (ROC) curve analysis determined the optimal threshold of the relative SUV anticipating 5-ALA-induced fluorescence.

Results

During resection a vivid fluorescence was present in all patients. Histology revealed glioblastomas in 11 cases, an anaplastic astrocytoma in one case and a low-grade astrocytoma in one case. The median FET SUVR was higher in areas corresponding to the fluorescent tumour compared with the non-fluorescent normal brain (2.321 vs 1.142, p < 0.0001, t-test). A SUVR greater than 1.374 predicted the fluorescence with a sensitivity of 0.87 [95% confidence interval (CI): 0.74–0.94] and a specificity of 0.94 (CI: 0.84–0.99). The area under the ROC curve was 0.9656 (CI: 0.9364–0.9948).

Conclusions

FET uptake predicts the 5-ALA-induced fluorescence in glioma patients. Thus, FET-PET provides useful information for planning glioma resection.

Keywords

GlioblastomaF18-FETPET5-ALAFluorescence

Copyright information

© Springer-Verlag 2009