Intrathecal chemotherapy delivered by a lumbar-thecal catheter in metastatic medulloblastoma: a case illustration
First Online: 11 April 2008 Received: 05 March 2008 Accepted: 10 March 2008 DOI:
Cite this article as: Clayton, J., Vloeberghs, M., Jaspan, T. et al. Acta Neurochir (Wien) (2008) 150: 709. doi:10.1007/s00701-008-1577-y Summary Background. Medulloblastoma is the most common malignant brain tumour in children. Despite recent advances, the prognosis in high risk patients remains poor. Further improvement in survival is dependent upon the development of strategies to attack the tumour more effectively, but with less toxicity. Intrathecal chemotherapy, is an ideal but currently underused method of directly targeting residual tumour within the area of resection and the leptomeningeal disease commonly associated with this tumour. Method. We describe the case of a 12 yr old child with metastatic medulloblastoma, who received intrathecal topotecan via a spinal catheter. Conclusion. This method represents a simple, safe and effective method of delivering an even and widespread distribution of drug within the cerebrospinal fluid (CSF) of the neuroaxis. With new agents being identified and others in the early stages of development, intrathecal chemotherapy may emerge as an important therapeutic option to consider when faced with such challenging cases. Keywords: Metastatic medulloblastoma; primitive neuroectodermal tumour; intrathecal chemotherapy; topotecan.
Correspondence: Miss Juliet Clayton, Queens Medical Centre, Department of Neurosurgery, West Block, C Floor, Derby Road, Nottingham NG7 2UH, UK.
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