Microchimica Acta

, Volume 171, Issue 3, pp 423–429

Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination

  • Xianwen Kan
  • Tingting Liu
  • Hong Zhou
  • Chen Li
  • Bin Fang
Original Paper

DOI: 10.1007/s00604-010-0455-5

Cite this article as:
Kan, X., Liu, T., Zhou, H. et al. Microchim Acta (2010) 171: 423. doi:10.1007/s00604-010-0455-5

Abstract

An electrochemical sensor for theophylline (ThPh) was prepared by electropolymerizing o-phenylenediamine on a glassy carbon electrode in the presence of ThPh via cyclic voltammetry, followed by deposition of gold nanoparticles using a potentiostatic method. The effects of pH, ratio between template molecule and monomer, number of cycles for electropolymerization, and of the solution for extraction were optimized. The current of the electro-active model system hexacyanoferrate(III) and hexacyanoferrate(IV) decreased linearly with successive addition of ThPh in the concentration range between 4.0 × 10−7 ~ 1.5 × 10−5 mol·L−1 and 2.4 × 10−4 ~ 3.4 × 10−3 mol·L−1, with a detection limit of 1.0 × 10−7 mol·L−1. The sensor has an excellent recognition capability for ThPh compared to structurally related molecules, can be regenerated and is stable.

https://static-content.springer.com/image/art%3A10.1007%2Fs00604-010-0455-5/MediaObjects/604_2010_455_Figa_HTML.gif
Figure

In this paper, an electrochemical sensor for theophylline (ThPh) was prepared by electropolymerizing o-phenylenediamine (o-PD) on a glassy carbon electrode in the presence of ThPh via cyclic voltammetry, followed by deposition of gold nanoparticles to enhance the sensitivity of the sensor. Therefore, the sensor showed a high sensitivity for ThPh determining. Peak current of [Fe(CN)6]3−/[Fe(CN)6]4− varied linearly with the concentration of ThPh in the range of 4.0×10-7~1.5×10-5 mol·L-1 and 2.4×10-4~3.4×10-3 mol·L-1, and the detection limit reached 1.0×10-7 mol·L-1. Compared to structurally related molecules, the sensor also has a high recognition capability for ThPh. With excellent regeneration property and stability, the present sensor maybe provides a new class of polymer modified electrodes for sensor applications.

Keywords

Molecular imprinted polymerElectrochemical sensorAu nanoparticlesTheophyllineRecognition

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Xianwen Kan
    • 1
  • Tingting Liu
    • 1
  • Hong Zhou
    • 1
  • Chen Li
    • 1
  • Bin Fang
    • 1
  1. 1.College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-BiosensingAnhui Normal UniversityWuhuPeople’s Republic of China