Surgery Today

, Volume 33, Issue 2, pp 95–100

The Significance of Perineural Invasion as a Prognostic Factor in Patients with Gastric Carcinoma

  • Nüvit Duraker
  • Servet Şişman
  • Günay Can

DOI: 10.1007/s005950300020

Cite this article as:
Duraker, N., Şişman, S. & Can, G. Surg Today (2003) 33: 95. doi:10.1007/s005950300020


Purpose: Few studies have investigated the prognostic significance of perineural invasion (PNI) in gastric cancer. Therefore, we examined the association between PNI and clinicopathological factors and the effect of PNI on overall survival in patients with gastric carcinoma.

Methods: Paraffin sections of surgical specimens from 354 patients who underwent gastric resection were stained with hematoxylin and eosin. PNI was assessed histologically as positive when cancer cells were seen in the perineurium or neural fascicles. Survival analysis was done in 219 patients with T2,3,4 tumors who underwent potentially curative resection. Data were collected prospectively.

Results: PNI was positive in 211 of the 354 patients (59.6%). The ratio of undifferentiated tumors, tumors with vascular invasion, and lymph node metastasis was significantly higher in the PNI-positive patients than in the PNI-negative patients (P < 0.0001 for all three associations). As the depth of mural invasion increased, so did PNI positivity (P < 0.0001). The overall survival of the PNI-positive patients was significantly worse than that of the PNI-negative patients in the univariate analysis (P = 0.0009). However, PNI had no independent prognostic significance in the multivariate Cox proportional hazards model analysis. When the patients were separated into subgroups, PNI had prognostic value in patients with T3 tumors (P = 0.036) and no lymph node metastasis (P = 0.005) in the univariate analysis, but no prognostic significance in the multivariate analysis.

Conclusions: Although the incidence of PNI is high in gastric carcinoma and increases with the progression of disease, it does not provide any additional information to the classical prognostic parameters.

Key words Gastric cancerNeural invasionPrognosis

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Nüvit Duraker
    • 1
  • Servet Şişman
    • 2
  • Günay Can
    • 3
  1. 1. Fifth Department of Surgery andTR
  2. 2. Department of Pathology, SSK Okmeydanı Training Hospital, Istanbul, TurkeyTR
  3. 3. Department of Public Health and Biostatistics, Istanbul University Cerrahpaşa Medical School, Istanbul, TurkeyTR