Significance of Serum Endotoxin and Antiendotoxin Antibody Levels in Predicting the Severity of Acute Pancreatitis
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
A close association between endotoxemia and acute pancreatitis has been reported, and attempts have been made to predict the severity of pancreatitis by estimating the levels of endotoxin. The present study was designed to correlate endotoxemia with the severity and complications of acute pancreatitis as graded by contrast-enhanced computed tomography and Blamey's criteria.
We examined 20 patients with acute pancreatitis, using Blamey's criteria to assess the severity of pancreatitis. The endotoxin level was estimated by the Limulus Amoebocyte Lysate method and the antiendotoxin antibody level was assayed by the enzyme-linked immunoassay technique measuring combined levels of IgG and IgM.
Severe pancreatitis was confirmed in 9 of the 20 patients, 17 (85%) of whom were found to have endotoxemia. There was no correlation between the presence and level of endotoxemia and the severity of pancreatitis; however, antiendotoxin antibody titers were significantly lower in patients with severe disease (P < 0.05), those who suffered of major complications (P < 0.01), and those who died of the disease (P < 0.01).
The findings of this study demonstrated that the presence of endotoxemia accompanied by a fall in antiendotoxin antibody titer predicts poor outcome in patients with acute pancreatitis.
- Significance of Serum Endotoxin and Antiendotoxin Antibody Levels in Predicting the Severity of Acute Pancreatitis
Volume 32, Issue 7 , pp 602-607
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Key words Acute pancreatitis
- Antiendotoxin antibody
- Industry Sectors
- Author Affiliations
- A1. Departments of Surgery and, IN
- A2. Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India, IN