Surgery Today

, Volume 29, Issue 10, pp 1083–1087

Malignant rhabdoid tumor of the colon: Report of a case

  • Izumi Nakamura
  • Keiichi Nakano
  • Kouichi Nakayama
  • Yoshimasa Ishii
  • Kazutoshi Ohta
  • Masayasu Takahashi
  • Toshio Yamada
  • Keiko Yamaguchi
  • Hideo Sakuma
  • Atsuo Tsuchiya
  • Seiichi Takenoshita
Case Reports

DOI: 10.1007/s005950050649

Cite this article as:
Nakamura, I., Nakano, K., Nakayama, K. et al. Surg Today (1999) 29: 1083. doi:10.1007/s005950050649

Abstract

A malignant rhabdoid tumor of the colon is very rare and only three cases have been previously described. A 76-year-old man was admitted to the hospital complaining of epigastralgia. An elastic mass was palpable in the right upper abdomen. A barium enema and endoscopic examination showed a giant gyrate tumor arising from the cecum. Abdominal ultrasonography and a computed tomography scan revealed the tumor to be located in the colon associated with multiple liver metastases and gallbladder stones. A right colectomy and cholecystectomy were thus performed. The tumor was histologically composed of sheets of large round and polygonal nuclei with vesicular chromatin, and abundant acidophilic cytoplasm, often containing hyalin-like inclusion. The cytoplasm was positive for vimentin and neuron-specific enolase, and hyaline globules of the rhabdoid tumor cells stained positive for cytokeratin in some cells. Transmission electron microscopy showed characteristic rhabdoid cells with an aggregation of intermediate filaments. A histologic diagnosis of malignant rhabdoid tumor of the colon was made. The tumor demonstrated several unusual findings for malignant rhabdoid tumors including diploidy by a flow cytometric analysis, and positive nuclear immunohistochemical staining for p53 protein and Ki-67 antigen. We report herein the third known case of a pure colonic rhabdoid tumor.

Key Words

rhabdoid tumorcolon neoplasmp53 mutationKi-67 antigenDNA flow cytometry

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • Izumi Nakamura
    • 1
  • Keiichi Nakano
    • 2
  • Kouichi Nakayama
    • 2
  • Yoshimasa Ishii
    • 2
  • Kazutoshi Ohta
    • 2
  • Masayasu Takahashi
    • 2
  • Toshio Yamada
    • 2
  • Keiko Yamaguchi
    • 3
  • Hideo Sakuma
    • 3
  • Atsuo Tsuchiya
    • 1
  • Seiichi Takenoshita
    • 1
  1. 1.Department of Surgery IIFukushima Medical University School of MedicineFukushimaJapan
  2. 2.Department of SurgeryOhta General HospitalKoriyamaJapan
  3. 3.Department of PathologyOhta General HospitalKoriyamaJapan