Surgery Today

, Volume 44, Issue 7, pp 1336–1342

The DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study

Authors

    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
    • Department of General Visceral and Transplantation SurgeryCharité, University Medicine
  • Nadine Al-Abadi
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
  • Angelika Dürr
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
  • Roberta Bova
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
  • Frederick Klauschen
    • Institute of PathologyCharité University Hospital
  • Albrecht Stenzinger
    • Institute of PathologyUniversity Hospital
  • Marcus Bahra
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
  • Hussein Al-Abadi
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
  • Peter Neuhaus
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
  • Daniel Seehofer
    • Department of General Visceral and Transplantation SurgeryCharité University Hospital
Original Article

DOI: 10.1007/s00595-013-0701-7

Cite this article as:
Kamphues, C., Al-Abadi, N., Dürr, A. et al. Surg Today (2014) 44: 1336. doi:10.1007/s00595-013-0701-7

Abstract

Purpose

Predictive markers for risk stratification among patients with intrahepatic cholangiocarcinoma (IHC) are still lacking. Therefore, recent studies have focused on identifying the biological aspects of tumors that can provide more information about the tumor aggressiveness. The aim of this study was to prospectively evaluate the prognostic potential of the DNA index in patients undergoing liver resection for IHC.

Methods

In a prospective long-term follow-up study, the DNA index of 65 IHC patients undergoing liver resection was assessed by DNA image cytometry, and this parameter, as well as standard histopathological parameters, correlated with the patient survival.

Results

The mean DNA index was 1.69 ± 0.66 (range, 0.9–4.3). The univariate survival analysis showed that the DNA index (p = 0.024) and tumor stage (p = 0.017) were associated with patient survival, whereas all other standard histopathological factors had no predictive value. The multivariate analysis identified the DNA index (p = 0.050) and tumor stage (p = 0.028) as independent prognostic parameters.

Conclusions

The DNA index is an independent predictive marker for IHC after liver resection. It is superior to most standard histopathological parameters and can be assessed pre- and postoperatively. Therefore, the DNA index might represent a promising tool in the decision-making process for patients with IHC.

Keywords

Cholangiocarcinoma DNA ploidy Prognosis

Copyright information

© Springer Japan 2013