Surgery Today

, Volume 43, Issue 4, pp 439–445

Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case

  • Mikihiro Kohno
  • Ken Shirabe
  • Yohei Mano
  • Jun Muto
  • Takashi Motomura
  • Kazuki Takeishi
  • Takeo Toshima
  • Masanori Yoshimatsu
  • Hideki Ijichi
  • Noboru Harada
  • Shinichi Aishima
  • Hideaki Uchiyama
  • Tomoharu Yoshizumi
  • Akinobu Taketomi
  • Yoshihiko Maehara
Case Report

DOI: 10.1007/s00595-012-0202-0

Cite this article as:
Kohno, M., Shirabe, K., Mano, Y. et al. Surg Today (2013) 43: 439. doi:10.1007/s00595-012-0202-0

Abstract

This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.

Keywords

G-CSF-producing tumorHepatocellular carcinomaLeukocytosisSurgical resectionImmunohistochemistry

Copyright information

© Springer 2012

Authors and Affiliations

  • Mikihiro Kohno
    • 1
  • Ken Shirabe
    • 1
  • Yohei Mano
    • 1
    • 2
  • Jun Muto
    • 1
  • Takashi Motomura
    • 1
  • Kazuki Takeishi
    • 1
  • Takeo Toshima
    • 1
  • Masanori Yoshimatsu
    • 1
  • Hideki Ijichi
    • 1
  • Noboru Harada
    • 1
  • Shinichi Aishima
    • 2
  • Hideaki Uchiyama
    • 1
  • Tomoharu Yoshizumi
    • 1
  • Akinobu Taketomi
    • 1
  • Yoshihiko Maehara
    • 1
  1. 1.Department of Surgery and Science, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan