Surgery Today

, 41:1325

Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan

Authors

  • Susumu Eguchi
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Akihiko Soyama
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
    • Japan Foundation for AIDS Prevention
  • Masaaki Hidaka
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Mitsuhisa Takatsuki
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Izumi Muraoka
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Tetsuo Tomonaga
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Takashi Kanematsu
    • Department of SurgeryNagasaki University Graduate School of Biomedical Sciences
Review Article

DOI: 10.1007/s00595-010-4556-x

Cite this article as:
Eguchi, S., Soyama, A., Hidaka, M. et al. Surg Today (2011) 41: 1325. doi:10.1007/s00595-010-4556-x

Abstract

Liver transplantation for patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) remains challenging. The advent of highly active antiretroviral therapy (HAART) for HIV has reduced mortality from opportunistic infection related to acquired immunodeficiency syndrome dramatically, while about 50% of patients die of end-stage liver cirrhosis resulting from HCV. In Japan, liver cirrhosis frequently develops after HCV-HIV coinfection resulting from previously transfused infected blood products for hemophilia. The problems of liver transplantation for those patients arise from the need to control calcineurin inhibitor with HAART drugs, the difficulty of using interferon after liver transplantation with HAART, and the need to control intraoperative coagulopathy associated with hemophilia. We review published reports of liver transplantation for these patients in the updated world literature.

Key words

Liver transplantationHepatitis C virusHuman immunodeficiency virusCoinfectionHighly active antiretroviral therapy

Copyright information

© Springer 2011