Surgery Today

, Volume 41, Issue 1, pp 18–23

Human adipose-derived stem cells: Potential clinical applications in surgery

Authors

  • Tohru Utsunomiya
    • Cancer Clinical Cooperation CenterTokushima University Hospital
    • Department of SurgeryThe University of Tokushima
  • Mitsuo Shimada
    • Department of SurgeryThe University of Tokushima
  • Satoru Imura
    • Department of SurgeryThe University of Tokushima
  • Yuji Morine
    • Department of SurgeryThe University of Tokushima
  • Tetsuya Ikemoto
    • Department of SurgeryThe University of Tokushima
  • Hiroki Mori
    • Department of SurgeryThe University of Tokushima
  • Jun Hanaoka
    • Department of SurgeryThe University of Tokushima
  • Shuichi Iwahashi
    • Department of SurgeryThe University of Tokushima
  • Yu Saito
    • Department of SurgeryThe University of Tokushima
  • Hideki Iwaguro
    • Cytori Therapeutics, Inc.
Review Article

DOI: 10.1007/s00595-010-4415-9

Cite this article as:
Utsunomiya, T., Shimada, M., Imura, S. et al. Surg Today (2011) 41: 18. doi:10.1007/s00595-010-4415-9

Abstract

Regenerative medicine is emerging as a rapidly evolving field of research and therapeutics. Stem cells hold great promise for future translational research and clinical applications in many fields. Much research has focused on mesenchymal stem cells isolated from bone marrow in vitro and in vivo; however, bone marrow procurement causes considerable discomfort to the patient and yields a relatively small number of harvested cells. By contrast, adipose tissue represents an abundant and easily accessible source of adult stem cells, termed adipose-derived stem cells (ADSCs), with the ability to equally differentiate along multiple lineage pathways. These stem cells have angiogenic properties, possibly because of their secretion of cytokines. They may also play a role in healing acute and chronic tissue damage. Subsequently, they have a wide range of potential clinical implications. This article reviews the potential preclinical and clinical applications of mesenchymal stem cells, especially ADSCs, in surgery.

Key words

Adipose tissue Regenerative medicine Mesenchymal stromal cell Tissue engineering Differentiation

Copyright information

© Springer 2011