Surgery Today

, Volume 39, Issue 7, pp 619–623

Primary adenosquamous carcinoma of the colon: Report of five cases

  • Yingchun Dong
  • Jiandong Wang
  • Henghui Ma
  • Hangbo Zhou
  • Guangming Lu
  • Xiaojun Zhou
Case Report

DOI: 10.1007/s00595-008-3884-6

Cite this article as:
Dong, Y., Wang, J., Ma, H. et al. Surg Today (2009) 39: 619. doi:10.1007/s00595-008-3884-6

Abstract

Primary adenosquamous cell carcinomas (Ad-SCCs) of the colon and rectum are rare malignancies with a poor prognosis, in comparison to adenocarcinoma alone. Different roles of human papilloma virus (HPV) in its pathogenesis have been reported and the role of P16 in Ad-SCCs has not been explored. This report presents five cases of Ad-SCC of the colon to explore the clinicopathological features and the roles of P16, HPV 6/11, and 16/18. There was no confirmed evidence to support the relationship between the infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon. P16 overexpression was not related to HPV carcinogenesis and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.

Key words

Colorectal carcinoma Primary adenosquamous carcinoma Human papilloma virus P16 Prognosis 

Copyright information

© Springer 2009

Authors and Affiliations

  • Yingchun Dong
    • 1
  • Jiandong Wang
    • 2
  • Henghui Ma
    • 2
  • Hangbo Zhou
    • 2
  • Guangming Lu
    • 2
  • Xiaojun Zhou
    • 2
  1. 1.Department of AnesthesiologyMedical School of Nanjing University, Nanjing Stomatology HospitalNanjingPR China
  2. 2.Department of PathologyNanjing Jinling HospitalNanjingPR China