Surgery Today

, Volume 36, Issue 6, pp 559–562

Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis Successfully Treated by Immunotherapy with CD3-Activated T Cells and Dendritic Cells After Surgery: Report of a Case

Authors

  • Ryota Higuchi
    • Department of Surgery, Institute of GastroenterologyTokyo Women's Medical University
  • Masakazu Yamamoto
    • Department of Surgery, Institute of GastroenterologyTokyo Women's Medical University
  • Takashi Hatori
    • Department of Surgery, Institute of GastroenterologyTokyo Women's Medical University
  • Koichi Shimizu
    • Department of Surgery, Institute of GastroenterologyTokyo Women's Medical University
  • Kenichirou Imai
    • Department of Surgery, Institute of GastroenterologyTokyo Women's Medical University
  • Ken Takasaki
    • Department of Surgery, Institute of GastroenterologyTokyo Women's Medical University
Article

DOI: 10.1007/s00595-006-3201-1

Cite this article as:
Higuchi, R., Yamamoto, M., Hatori, T. et al. Surg Today (2006) 36: 559. doi:10.1007/s00595-006-3201-1

Abstract

Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or peptide-pulsed dendritic cells. Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion. The patient has been alive without recurrence for 3 years 6 months since her operation.

Key words

Intrahepatic cholangiocarcinoma Lymph node metastasis

Copyright information

© Springer-Verlag Tokyo 2006