Review Article

Surgery Today

, Volume 35, Issue 9, pp 705-710

First online:

Liver Repopulation: A New Concept of Hepatocyte Transplantation

  • Yujo KawashitaAffiliated withDepartment of Transplantation, Digestive Surgery, Nagasaki University Graduate School of Biomedical Science
  • , Chandan GuhaAffiliated withDepartment of Radiation Oncology, Albert Einstein College of Medicine
  • , Kosho YamanouchiAffiliated withDepartment of Radiation Oncology, Albert Einstein College of Medicine
  • , Yuichiro ItoAffiliated withDepartment of Transplantation, Digestive Surgery, Nagasaki University Graduate School of Biomedical Science
  • , Yukio KamoharaAffiliated withDepartment of Transplantation, Digestive Surgery, Nagasaki University Graduate School of Biomedical Science
  • , Takashi KanematsuAffiliated withDepartment of Transplantation, Digestive Surgery, Nagasaki University Graduate School of Biomedical Science

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Abstract

Hepatocyte transplantation has been recognized as an alternative strategy for organ transplantation because the supply of donor livers is limited. However, in conventional hepatocyte transplantation, only 1%–10% of the liver replaced with transplanted hepatocytes. Recently a novel concept termed “liver repopulation” has been established, where the whole recipient liver can be replaced by a small number of donor hepatocytes. To induce liver repopulation, growth advantage of the donor hepatocytes against the host liver seems to be required according to the data of previous studies. Additionally, various cell sources, including bone marrow cells and other stem cells, could potentially be used as donor cells for liver repopulation. In this article, we discuss recent progress and future perspectives of this emerging technology.

Key words

Hepatocyte transplantation Liver repopulation