Acta Diabetologica

, Volume 50, Issue 1, pp 1–20

Pathophysiology and treatment of diabetic retinopathy

Authors

    • Department of Ophthalmology, Scientific Institute San RaffaeleUniversity Vita-Salute
  • Rosangela Lattanzio
    • Department of Ophthalmology, Scientific Institute San RaffaeleUniversity Vita-Salute
  • Ilaria Zucchiatti
    • Department of Ophthalmology, Scientific Institute San RaffaeleUniversity Vita-Salute
  • Claudia Del Turco
    • Department of Ophthalmology, Scientific Institute San RaffaeleUniversity Vita-Salute
Review Article

DOI: 10.1007/s00592-012-0449-3

Cite this article as:
Bandello, F., Lattanzio, R., Zucchiatti, I. et al. Acta Diabetol (2013) 50: 1. doi:10.1007/s00592-012-0449-3

Abstract

In the past years, the management of diabetic retinopathy (DR) relied primarily on a good systemic control of diabetes mellitus, and as soon as the severity of the vascular lesions required further treatment, laser photocoagulation or vitreoretinal surgery was done to the patient. Currently, even if the intensive metabolic control is still mandatory, a variety of different clinical strategies could be offered to the patient. The recent advances in understanding the complex pathophysiology of DR allowed the physician to identify many cell types involved in the pathogenesis of DR and thus to develop new treatment approaches. Vasoactive and proinflammatory molecules, such as vascular endothelial growth factor (VEGF), play a key role in this multifactorial disease. Current properly designed trials, evaluating agents targeting VEGF or other mediators, showed benefits in the management of DR, especially when metabolic control is lacking. Other agents, directing to the processes of vasopermeability and angiogenesis, are under investigations, giving more hope in the future management of this still sight-threatening disease.

Keywords

Diabetic macular edemaProliferative diabetic retinopathyLaserIntravitreal anti-VEGFDexamethasone implantVitrectomy

Copyright information

© Springer-Verlag Italia 2012