Original Article

Acta Diabetologica

, Volume 50, Issue 1, pp 81-87

Factors associated with a rapid normalization of HbA1c in newly diagnosed type 2 diabetes patients seen in a specialist setting

  • C. B. GiordaAffiliated withMetabolism and Diabetes Unit, ASL Email author 
  • , M. F. MulasAffiliated withMetabolism and Diabetes Unit
  • , V. ManicardiAffiliated withMontecchio Hospital
  • , C. SuraciAffiliated withMetabolism and Diabetes Unit, Pertini Hospital
  • , P. GuidaAffiliated withCardiology Unit, Emergency and Organ Transplantation Department, University of Bari
  • , L. MarafettiAffiliated withMetabolism and Diabetes Unit, ASL
  • , E. NadaAffiliated withChaira Medica Association
  • , S. GentileAffiliated withUniversity of Naples

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The time to achieve good metabolic control after diagnosis is essential for type 2 diabetes patients because it can influence long-term prognosis. This study aimed to elucidate the predictive role of several clinical and organization factors in normalizing metabolism within 6 months. A multi-centered, retrospective, observational study on 960 patients, with diabetes duration of 12 months or less, consecutively seen in 123 Italian clinics, was undertaken. Information about clinic’s organization, along with data abstracted from medical records at enrollment (first visit) and after 6 months (follow-up visit), was collected. At 6 months, HbA1c dropped by −3.1 ± 2.2 points in those who achieved HbA1c <7 % (responders), whereas in non-responders (HbA1c ≥7 %), the mean reduction was −1.8 ± 1.9. The intervention markedly reduced lipids, blood pressure, BMI, and waist circumference, especially in responders. The presence of a diabetes team correlated with a likelihood of HbA1c normalization (OR 1.94, 1.17–3.22). By contrast, indicators of advanced disease such as previous retinopathy (0.53, 0.29–0.98), use of secretagogues (0.40, 0.25–0.64), high levels of HbA1c at first visit and related insulin use emerged as adverse factors. Early detection of diabetes, along with human resources and organization, was found to play a crucial role in rapidly attaining good metabolic control.


HbA1c normalization Type 2 diabetes treatment Organizational factors Clinical factors