Acta Diabetologica

, Volume 49, Issue 2, pp 159–164

Impaired diffusing capacity for carbon monoxide in children with type 1 diabetes: is this the first sign of long-term complications?

Authors

    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
    • Department of Pediatrics, “Ospedale Luigi Sacco”University of Milano
  • Marco Morelli
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
  • Maurizio Rizzi
    • Respiratory Medicine, Luigi Sacco HospitalUniversity of Milano
  • Simona Borgonovo
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
  • Alessandra De Palma
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
  • Chiara Mameli
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
  • Elisa Giani
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
  • Silvia Beretta
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
  • Gian Vincenzo Zuccotti
    • Department of Paediatrics, “Luigi Sacco Hospital”University of Milano
Original Article

DOI: 10.1007/s00592-011-0353-2

Cite this article as:
Scaramuzza, A.E., Morelli, M., Rizzi, M. et al. Acta Diabetol (2012) 49: 159. doi:10.1007/s00592-011-0353-2

Abstract

We assessed the presence of lung dysfunction in children with type 1 diabetes, evaluated as reduced diffusing capacity of the lung for carbon monoxide (DLCO), and its components: membrane diffusing capacity (DM) and pulmonary capillary blood volume (Vc). A total of 42 children, aged 15.6 ± 3.8 years, with type 1 diabetes for 8.3 ± 5.5 years, and 30 healthy age and sex-matched peers were recruited for the study. Lung volumes and spirometric dynamic parameters were assessed by plethysmography. Single-breath DLCO was measured according to international recommendation. DM and Vc volume were calculated. Lung volumes were significantly reduced in young patients with type 1 diabetes when compared to controls. Moreover, DLCO was reduced in patients compared to controls (78% ± 16% vs. 120% ± 1%, P = 0.0001). However, when differentiating DM and Vc compartments, we observed a significant impairment only about Vc (34 ± 20 ml vs. 88 ± 18 ml; P = 0.0001), while no difference was observed about DM compartment (23 ± 4 vs. 26 ± 3 ml/min/mmHg, P = 0.798). Whether this might be seen as the “first” sign of microangiopathic involvement in patients with type 1 diabetes has to be confirmed on larger groups but is still fascinating. Meanwhile, we suggest to screen DLCO in all patients with type 1 diabetes.

Keywords

AdolescentsChildrenLung diffusionLung functionMicroangiopathic complicationsType 1 diabetes

Abbreviations

BMI

Body mass index

DLCO

Diffusing capacity of the lung for carbon monoxide

DM

Membrane diffusing capacity

FEV1

Forced expiratory volume in 1 s

FVC

Forced vital capacity

HbA1c

Glycated hemoglobin

KCO

Carbon monoxide transfer coefficient

RV

Residual volume

TLC

Total lung capacity

VC

Vital capacity

Vc

Pulmonary capillary blood volume

Copyright information

© Springer-Verlag 2011