Acta Diabetologica

, Volume 48, Issue 2, pp 113–119

Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes

  • Sheng-Chiang Su
  • Dee Pei
  • Chang-Hsun Hsieh
  • Fone-Ching Hsiao
  • Chung-Ze Wu
  • Yi-Jen Hung
Original Article

DOI: 10.1007/s00592-009-0171-y

Cite this article as:
Su, S., Pei, D., Hsieh, C. et al. Acta Diabetol (2011) 48: 113. doi:10.1007/s00592-009-0171-y

Abstract

This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI ≦ 25 kg/m2, N = 23) and an obese group (OBYDM, BMI ≧ 25 kg/m2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-β, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P < 0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P < 0.01 and P < 0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-α levels in OBYDM, whereas higher TNF-α and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = −0.44, P < 0.005), CRP (R = 0.28, P < 0.05), TNF-α (R = 0.42, P < 0.005) and IL-6 (R = 0.33, P < 0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = −0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.

Keywords

Pro-inflammatory cytokinesAdiponectinYoung diabetes

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Sheng-Chiang Su
    • 1
  • Dee Pei
    • 2
  • Chang-Hsun Hsieh
    • 1
  • Fone-Ching Hsiao
    • 1
  • Chung-Ze Wu
    • 3
  • Yi-Jen Hung
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of Internal MedicineTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan, ROC
  2. 2.Division of Endocrinology and Metabolism, Department of Internal MedicineCardinal Tien HospitalXindianTaiwan, ROC
  3. 3.Division of Endocrinology and Metabolism, Department of Internal MedicineTaipei Medical University-Shuang Ho HospitalTaipeiTaiwan, ROC