Acta Diabetologica

, Volume 47, Issue 2, pp 119–124

Circulating vascular endothelial growth factor in the normo- and/or microalbuminuric patients with type 2 diabetes mellitus

Authors

    • National Center of Hemostasis and Thrombosis, Jessenius Faculty of MedicineComenius University
  • Peter Chudý
    • National Center of Hemostasis and Thrombosis, Jessenius Faculty of MedicineComenius University
  • Ján Staško
    • National Center of Hemostasis and Thrombosis, Jessenius Faculty of MedicineComenius University
  • Peter Galajda
    • Clinic of Internal Medicine 1, Jessenius Faculty of MedicineComenius University
  • Pavol Hollý
    • National Center of Hemostasis and Thrombosis, Jessenius Faculty of MedicineComenius University
  • Robert Vyšehradský
    • Clinic of Pneumophthisiology, Jessenius Faculty of MedicineComenius University
  • Marián Mokáň
    • Clinic of Internal Medicine 1, Jessenius Faculty of MedicineComenius University
Original Article

DOI: 10.1007/s00592-009-0127-2

Cite this article as:
Kubisz, P., Chudý, P., Staško, J. et al. Acta Diabetol (2010) 47: 119. doi:10.1007/s00592-009-0127-2

Abstract

Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using enzyme-linked immunosorbent assay in all subjects. VEGF was significantly higher in NAU compared to controls. The difference between MAU and controls was not statistically significant, but there was a trend toward significance. Only TAFI correlated with VEGF in MAU. An observed significant increase of serum VEGF level already in NAU suggests that serum VEGF could be a sensitive predictor of endothelial dysfunction in type 2 diabetes.

Keywords

VEGFDiabetes mellitus type 2Endothelial dysfunction

Copyright information

© Springer-Verlag 2009