Acta Diabetologica

, Volume 46, Issue 2, pp 79–84

The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes

  • Sabrina Prudente
  • Eleonora Morini
  • Vincenzo Trischitta
Review Article

DOI: 10.1007/s00592-008-0087-y

Cite this article as:
Prudente, S., Morini, E. & Trischitta, V. Acta Diabetol (2009) 46: 79. doi:10.1007/s00592-008-0087-y

Abstract

Type 2 diabetes is becoming epidemic. The personal and social burden imposed by diabetes will increase in the close future as its prevalence is expected to double in the next 15–20 years. Type 2 diabetes is caused by the combination of resistance to insulin action and inadequate insulin secretion. Despite the role of profound changes in individual environmental exposure is incontrovertible, several findings clearly indicate that type 2 diabetes and insulin resistance are also heritable. Among the several inhibitors of insulin signalling, which have been recently proposed as determinants of insulin resistance, is TRIB3, a mammalian tribbles homolog which affects insulin signalling at the level of Akt-2, a key modulator of insulin action in target cells. We here report data on a prevalent Q84R TRIB3 missense single nucleotide polymorphism (rs2295490) we first described few years ago. Several lines of evidences indicate that this amino-acid change is, in fact, a gain of function mutation with the potential to affect insulin signalling and thus, to increase the risk of insulin resistance and related clinical outcomes.

Keywords

Genetic susceptibilityComplex traitsInsulin resistance

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Sabrina Prudente
    • 1
    • 2
  • Eleonora Morini
    • 1
    • 3
  • Vincenzo Trischitta
    • 1
    • 2
    • 4
  1. 1.CSS-Mendel InstituteRomeItaly
  2. 2.Research Unit of Diabetes and Endocrine DiseasesCSS Scientific InstituteSan Giovanni RotondoItaly
  3. 3.Department of Clinical Sciences“Sapienza” UniversityRomeItaly
  4. 4.Department of Medical Pathophysiology“Sapienza” UniversityRomeItaly