Acta Diabetologica

, Volume 44, Issue 1, pp 14–19

Major childhood infectious diseases and other determinants associated with type 1 diabetes: a case-control study

  • M. T. Tenconi
  • G. Devoti
  • M. Comelli
  • M. Pinon
  • A. Capocchiano
  • V. Calcaterra
  • G. Pretti
  • and the Pavia T1DM Registry Group*
ORIGINAL

DOI: 10.1007/s00592-007-0235-9

Cite this article as:
Tenconi, M.T., Devoti, G., Comelli, M. et al. Acta Diabetol (2007) 44: 14. doi:10.1007/s00592-007-0235-9

Abstract

The objective of the study was to evaluate the association between infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0–29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non-diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Viral childhood diseases (OR 4.29; 95%CI 1.57–11.74) and bottle feeding (OR 1.83; 95%CI 1.08–3.09) were directly correlated to type 1 diabetes; an inverse correlation was found for vitamin D administration during lactation (0–14 years) (OR 0.31; 95%CI 0.11–0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08–0.46). Most associations of the studied variables confirm already known findings. The significant inverse correlation of type 1 diabetes with scarlet fever history is a peculiar finding, the meaning of which is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.

Key words

Type 1 diabetes mellitusChildhood infectionsCase-control studyScarlet fever

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • M. T. Tenconi
    • 1
  • G. Devoti
    • 2
  • M. Comelli
    • 3
  • M. Pinon
    • 1
  • A. Capocchiano
    • 1
  • V. Calcaterra
    • 4
  • G. Pretti
    • 1
  • and the Pavia T1DM Registry Group*
  1. 1.Department of Preventive MedicineUniversity of PaviaPaviaItaly
  2. 2.Department of Social Sciences and CommunicationUniversity of LecceLecceItaly
  3. 3.Department of Applied Health SciencesUniversity of PaviaPaviaItaly
  4. 4.Department of PediatricsSan Matteo HospitalPaviaItaly