Clinical and genetic features of childhood-onset Type 2 diabetes in Japan
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- Otabe, S., Nakayama, H., Fukutani, T. et al. Acta Diabetol (2007) 44: 181. doi:10.1007/s00592-007-0002-y
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We aimed to define the detailed clinical features of Japanese childhood-onset Type 2 diabetes mellitus (T2DM) patients who were followed-up, and to determine whether discernable characteristics were dissimilar or not from those of adult- and childhood-onset T2DM in other countries. Subjects were 22 patients (10 males and 12 females) under treatment without HNF-1α or mitochondrial gene mutations, and who were apparently diagnosed as diabetic when less than 15 years of age. Body mass indexes at onset in boys and girls were 25.8 ± 6.3 and 24.7 ± 3.6, respectively, with mean ages 13.3 ± 1.7 and 12.8 ± 2.0 years, respectively. Most patients had a short diabetic duration that required insulin treatment. One or both parents of 18 of the 22 T2DM subjects were diabetic and 7 subjects had a history of diabetes in their family across three generations. We demonstrated that a relatively large number of Japanese childhood-onset T2DM cases have a strong genetic factor, and are not necessarily related to excessive obesity. Furthermore, most required insulin therapy in the initial stages because of insufficient pancreatic β-cell reserves. This suggests that malfunction of pancreatic β-cells triggers hyperglycemia resulting in the requirement for insulin in Japanese some childhood-onset T2DM patients.