Acta Diabetologica

, Volume 40, Issue 4, pp 187–192

Importance of premeal injection time in insulin therapy: Humalog Mix25 is convenient for improved post-prandial glycemic control in type 2 diabetic patients with Italian dietary habits

  • C. Coscelli
  • G. Iacobellis
  • C. Calderini
  • R. Carleo
  • M. Gobbo
  • U. Di Mario
  • F. Leonetti
  • A. Galluzzo
  • V. Pirrone
  • M. Lunetta
  • P. Casale
  • F. Paleari
  • C. Falcelli
  • D. Valle
  • A. Camporeale
  • D. Merante
ORIGINAL

DOI: 10.1007/s00592-003-0110-2

Cite this article as:
Coscelli, C., Iacobellis, G., Calderini, C. et al. Acta Diabetol (2003) 40: 187. doi:10.1007/s00592-003-0110-2

Abstract.

We investigated the use, in a short period, of Humalog Mix25 (Mix25) in a twice-daily administration regimen compared to a twice-daily injection therapy with Humulin 30/70 (30/70) in diabetic patients with Italian dietary habits. We studied 33 type 2 diabetic patients aged 59.1±8.1 years, BMI 29.8±2.7 kg/m2, duration of diabetes and insulin therapy of 14.4±9.8 and 4.2±4.6 years, respectively. After a 4-day leadin period of twice-daily human insulin 30/70 treatment, patients were randomized to one of two treatment sequences: (1) a twice-daily regimen with Mix25 just 5 minutes before the morning and evening meals for 12 days, followed by a twicedaily therapy with human insulin 30/70 given 30 minutes before the morning and evening meals for an additional 12 days; or (2) the alternate sequence. Each patient underwent a mixed meal test: Humulin 30/70 was administered 30 minutes before the meal, while Mix25 was given 5 minutes before. The 2-hour post-prandial glucose concentration after breakfast was significantly lower during treatment with Mix25 than with Humulin 30/70 (157±43.2 vs. 180±43.2 mg/dl, p<0.05). The glycemic excursion after dinner on Mix25 treatment was significantly lower than with Humulin 30/70 (12.2±48.01 vs. 35.5±36.92 mg/dl, p<0.05). AUCglucose after Mix25 was lower than after Humulin 30/70. Glycemia after test meal was significantly lower with Mix25 than with Humulin 30/70. Insulin and free insulin concentrations after the test meal were significantly higher with Mix25 in comparison to Humulin 30/70. AUC serum insulin and free insulin curves after Mix25 were significantly higher than after Humulin 30/70 (p=0.028 and p=0.005, respectively). Twice-daily injections of Humalog Mix25, compared to human insulin 30/70 in type 2 diabetic patients with Italian dietary habits, provide improved and lasting post-prandial glycemic control, with the great convenience of the injection just before the meal.

Key words

Humalog Mix25 Type 2 diabetes 

Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • C. Coscelli
    • 1
  • G. Iacobellis
    • 2
  • C. Calderini
    • 1
  • R. Carleo
    • 3
  • M. Gobbo
    • 3
  • U. Di Mario
    • 2
  • F. Leonetti
    • 2
  • A. Galluzzo
    • 4
  • V. Pirrone
    • 4
  • M. Lunetta
    • 5
  • P. Casale
    • 5
  • F. Paleari
    • 6
  • C. Falcelli
    • 6
  • D. Valle
    • 7
  • A. Camporeale
    • 7
  • D. Merante
    • 7
  1. 1.Department of Internal Medicine and Metabolic DiseasesParma HospitalParmaItaly
  2. 2.Endocrinology Unit, Department of Clinical SciencesUniversity La Sapienza, Policlinico Umberto IRomeItaly
  3. 3.Diabetes ServiceSan Gennaro HospitalNaplesItaly
  4. 4.Medical ClinicP. Giaccone HospitalPalermoItaly
  5. 5.Diabetes ServiceCanizzaro HospitalCataniaItaly
  6. 6.Diabetes UnitSan Gerardo HospitalMonzaItaly
  7. 7.Medical DepartmentEli Lilly Italia Sesto FiorentinoFlorenceItaly

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