Acta Diabetologica

, Volume 40, Supplement 1, pp s187–s190

Body composition in advanced-stage Parkinson’s disease

  • M. L. Petroni
  • G. Albani
  • V. Bicchiega
  • S. Baudo
  • C. Vinci
  • A. Montesano
  • G. Izzo
  • P. Bertocco
  • S. Mazzotta
  • E. Zorzetto
  • F. Balzola
  • A. Mauro
ORIGINAL

DOI: 10.1007/s00592-003-0062-6

Cite this article as:
Petroni, M.L., Albani, G., Bicchiega, V. et al. Acta Diabetol (2003) 40(Suppl 1): s187. doi:10.1007/s00592-003-0062-6

Abstract.

Little is known about body composition in Parkinson’s disease (PD). We studied 35 patients (20 male, 15 female subjects; mean age 69.7±5.8 years) with advanced PD by anthropometry, dual-energy X-ray absorptiometry (DEXA), and serum 25-OH vitamin D measurement. Over 70% of patients had a disease duration of more than 4 years; all were on L-dopa treatment. Low levels of serum 25-OH vitamin D were present in 41% of the patients. The mean body mass index (BMI) was 25.3±4.3 kg/m2 (range 17.1–37.3). Mid-arm muscle circumference was below the 10th percentile in 23%. For whole-body mean (±SD) bone mineral density, the T score was below -1 SD in 35% of patients, and the Z score was below -1 SD in 24%. Percent fat mass measured with DEXA was 30.6±11.4% (range 10.1–45.5) in the overall sample; it was 21.1±8.8% (range 10.1–30.4) in male subjects and 38.1±9.2% (range 25.8–45.5) in female subjects. We conclude that advancedstage PD may show excess adiposity coexisting with depletion of lean body mass (sarcopenic obesity), in addition to decreased whole-body bone mineral density associated with low serum 25-OH vitamin D. A low level of physical activity and inadequate exposure to sunlight are likely to be among the putative causes.

Key words

Body composition Bone mineral density Fat mass Fat-free mass DEXA Parkinson’s disease 

Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • M. L. Petroni
    • 1
  • G. Albani
    • 3
  • V. Bicchiega
    • 1
  • S. Baudo
    • 3
  • C. Vinci
    • 1
  • A. Montesano
    • 2
  • G. Izzo
    • 1
  • P. Bertocco
    • 2
  • S. Mazzotta
    • 1
  • E. Zorzetto
    • 1
  • F. Balzola
    • 1
  • A. Mauro
    • 3
    • 4
  1. 1.Nutrition LaboratoryIstituto Auxologico Italiano PiancavalloVerbaniaItaly
  2. 2.Division of Physical Medicine and RehabilitationIstituto Auxologico Italiano Piancavallo VerbaniaItaly
  3. 3.Division of Neurology and NeurorehabilitationIstituto Auxologico Italiano PiancavalloVerbaniaItaly
  4. 4.Department of NeurosciencesUniversity of TurinItaly