General Review

European Journal of Orthopaedic Surgery & Traumatology

, Volume 23, Issue 2, pp 119-124

First online:

Viscosupplementation with hyaluronic acid in the treatment for cartilage lesions: a review of current evidence and future directions

  • Travis E. CleggAffiliated withDepartment of Orthopaedic Surgery, University of Louisville
  • , David CabornAffiliated withDepartment of Orthopaedic Surgery, University of Louisville
  • , Cyril MauffreyAffiliated withDepartment of Orthopaedic Surgery, University of LouisvilleOrthopedic Traumatology, Denver Health Medical Centre Email author 

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Diseases involving the articular cartilage are one of the leading causes of physical impairment among the adult population. While surgical technique and advancement have allowed us effective means at treating these diseases, this is not without significant risk and morbidity. With a very solid safety profile, viscosupplementation with hyaluronic acid (HA) derivatives has become an excellent modality for treating diseased articular cartilage. Recent literature supports the use of HA not only in the management of the pain associated with osteoarthritis but also as a disease-modifying agent as well. Further studies have started to define exciting new roles for viscosupplementation in the treatment for acute injuries to the joint microenvironment.


Viscosupplementation Hyaluronic acid Treatment of cartilage lesions