European Spine Journal

, Volume 22, Issue 10, pp 2249–2255

Biomechanical characteristics of cement/gelatin mixture for prevention of cement leakage in vertebral augmentation

  • Bin Meng
  • Ming Qian
  • Shao-Xiang Xia
  • Hui-Lin Yang
  • Zong-Ping Luo
Original Article

DOI: 10.1007/s00586-013-2886-2

Cite this article as:
Meng, B., Qian, M., Xia, S. et al. Eur Spine J (2013) 22: 2249. doi:10.1007/s00586-013-2886-2

Abstract

Purpose

This study evaluated whether or not the addition of gelatin micro-particles into the polymethyl methacrylate (PMMA) could reduce cement infiltration in cancellous bone of vertebra.

Methods

Gelatin micro-particles were prepared in various sizes and mixed with PMMA in different densities. Dynamic viscosity of the mixture was measured by a rotational rheometer. Fresh bovine vertebral bodies were sectioned into cylindrical samples. Permeability of the mixture through the samples was tested on a mechanical test machine, and calculated using Darcy’s law. The PMMA/gelatin mixture also underwent compressive and bending tests, and their structures were examined by scanning electron microscopy.

Results

The cement/gelatin mixture increased the viscosity. Significant reduction of cement permeability in cancellous bone was determined after the addition of the micro-particles. Micro-particles of 2 % in density and 125–250 μm in size decreased the permeability by 1/3 without any significant change of the cement viscosity. The biomechanical strength was unchanged in compression but decreased by up to 20 % in bending.

Conclusions

Gelatin micro-particles significantly increased the cement viscosity, reduced the permeability in cancellous bone of vertebra, decreased the flexural strength, but did not affect the compressive strength. Although it suggested a manageable approach in vertebral augmentation, the outcome should be further verified on a cadaveric model or an animal model before the mixture could be used safely and effectively in the clinical treatment.

Keywords

PMMAGelatinVertebraAugmentationBiomechanics

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Bin Meng
    • 1
  • Ming Qian
    • 1
  • Shao-Xiang Xia
    • 1
  • Hui-Lin Yang
    • 1
  • Zong-Ping Luo
    • 1
  1. 1.Department of Orthopedics of 1st Affiliated Hospital and Orthopedic InstituteSoochow UniversitySuzhouChina