European Spine Journal

, Volume 21, Supplement 6, pp 810–818

Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation

  • C. Weiler
  • M. Schietzsch
  • T. Kirchner
  • A. G. Nerlich
  • N. Boos
  • K. Wuertz
Original Article

DOI: 10.1007/s00586-011-1922-3

Cite this article as:
Weiler, C., Schietzsch, M., Kirchner, T. et al. Eur Spine J (2012) 21(Suppl 6): 810. doi:10.1007/s00586-011-1922-3

Abstract

Introduction

Intervertebral disc (IVD) degeneration is characterized as a multifactorial disease, in which the hereditary background is thought to be of high importance. Accordingly, one would expect all spinal levels (lumbar/cervical/thoracal) to be affected by above-average disc degeneration in genetically predisposed individuals. The aim of this study, therefore, was to analyze the amount of degenerative changes in different spine levels in humans from different ages.

Materials and methods

In detail, the presence, localization and abundance of histomorphological changes in the annulus fibrosus (AF) and nucleus pulposus (NP) in the cervical (C5/C6), thoracic (T2/T3) and lumbar (L2/L3) spine were investigated in complete autopsy IVD specimens (47 individuals) covering a complete age range (0–95 years).

Results

Results indicate that the highest degree of histo-degenerative changes were observed in the NP in all spine levels and showed an age-related expression pattern. With regard to the different spine levels, lumbar disc specimen showed significantly more degenerative changes compared to cervical and thoracic discs, whereas no statistical difference was observed between cervical and thoracic discs. In summary, highest grades of degeneration were observed in lumbar discs (especially in the NP). Intra-individual correlations between the degeneration score in the different levels showed a significant individual concordance.

Conclusions

The intra-individual correlation of degenerative changes in all three examined spine regions further supports the notion that individual, i.e. genetic factors are strong predisposing factor for the development of age-related disc alterations.

Keywords

Disc degenerationHistological degeneration score (HDS)Cervical, thoracic and lumbar spineAgingIntra-individual correlation

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • C. Weiler
    • 1
  • M. Schietzsch
    • 1
  • T. Kirchner
    • 1
  • A. G. Nerlich
    • 2
  • N. Boos
    • 3
    • 4
  • K. Wuertz
    • 3
    • 4
  1. 1.Institute of PathologyUniversity of MunichMunichGermany
  2. 2.Institute of PathologyAcademic Clinic Munich-BogenhausenMunichGermany
  3. 3.Spine Research Group, Competence Center for Applied Biotechnology and Molecular Medicine (CABMM)University of ZurichZurichSwitzerland
  4. 4.AOSpine Research NetworkDuebendorfSwitzerland