European Spine Journal

, Volume 18, Issue 3, pp 293–300

Upper cervical spine chordoma of C2–C3

  • Liang Jiang
  • Zhong Jun Liu
  • Xiao Guang Liu
  • Qing Jun Ma
  • Feng Wei
  • Yang Lv
  • Geng Ting Dang
Grand Rounds

DOI: 10.1007/s00586-009-0907-y

Cite this article as:
Jiang, L., Liu, Z.J., Liu, X.G. et al. Eur Spine J (2009) 18: 293. doi:10.1007/s00586-009-0907-y

Abstract

https://static-content.springer.com/image/art%3A10.1007%2Fs00586-009-0907-y/MediaObjects/586_2009_907_Figb_HTML.jpg
Chordoma is a rare low-grade malignant neoplasm derived from the remnants of the embryonic notochord. This locally invasive neoplasm is subject to recurrence after treatment. The median survival time is estimated to be 6.3 years. Various treatment approaches have been attempted, including radical excision, radiotherapy and chemotherapy. Treatment outcome is significantly influenced by the size and site of the chordoma. Recently, Imatinib, a molecular-targeted agent, has been shown to have antitumor activity in chordoma. Proton radiotherapy, stereotactic radiotherapy and intensity-modulated radiotherapy have also been used. Surgical treatment is still the primary choice for chordoma. It has become more aggressive in recent years, evolving from intralesional or partial excision to en bloc resection. However, upper cervical localizations make such en bloc resection in most cases not possible. We present and discuss the therapeutic challenges of a young female with large retropharyngeal chordoma who presented to our institution after conventional photon beam radiotherapy. This C2/3 tumor was classified IB according to the Enneking classification. It distributed to layers A–D and sectors 1–6 according to the Weinstein Boriani Biagini Classification. The left vertebral artery (VA) was encapsulated and displaced. One stage intralesional extracapsular tumor excision and reconstruction was achieved by combined bilateral high anterior cervical approaches and posterior approach. No recurrence or metastasis was observed 3 years after the operation. She returned to her previous occupation as office worker.

Keywords

ChordomaAtlantoaxial spineSurgery

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Liang Jiang
    • 1
  • Zhong Jun Liu
    • 1
  • Xiao Guang Liu
    • 1
  • Qing Jun Ma
    • 1
  • Feng Wei
    • 1
  • Yang Lv
    • 1
  • Geng Ting Dang
    • 1
  1. 1.Orthopaedic DepartmentPeking University Third HospitalBeijingChina