, Volume 21, Issue 6, pp 1407-1415
Date: 26 Jul 2011

Association of IL-10 gene promoter polymorphisms and non-Hodgkin lymphoma in Egyptian patients, relation to susceptibility, correlation with survival

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Abstract

The pathophysiology of non-Hodgkin’s lymphoma is still unknown. Many cytokines, including interleukin-10 (IL-10), play a role in the perpetuation of the disease. The aim of the study was to investigate the association of IL-10 gene promoter polymorphisms with non-Hodgkin lymphoma and to correlate with survival. Fifty patients with diffuse large B-cell lymphoma as well as 50 age- and sex-matched apparently healthy volunteers were genotyped for biallellic IL-10 gene promoter polymorphisms at positions −1082(A/G) and −3557(T/A) using polymerase chain reaction–restriction fragment length polymorphism. There were highly statistically significant differences between the two studied groups regarding results of IL-10 1082A/G polymorphism, for homozygous (GG) and heterozygous (AG) genotypes (p value <0.0001) but no statistically significant differences regarding homozygous (AA) genotype (p value = 0.7583). IL-10 3575T/A polymorphism revealed highly statistically significant differences between the two groups regarding homozygous (TT; p value <0.0001) and heterozygous (TA) genotypes (p value = 0.0007), but no significant difference found regarding homozygous (AA) genotype (p value = 0.1622). We did not find any associations between bad prognostic factors and any of the genotypes or alleles frequencies. Our results also reported that there was no impact of these polymorphisms on survival of lymphoma patients. IL-10 1082A/G and 3557T/A polymorphisms could be claimed as independent risk factors for susceptibility to lymphoma, regardless of any associated bad prognostic factors and without impact on overall survival.