Comparative Clinical Pathology

, Volume 21, Issue 3, pp 309–313

Complete blood count, total plasma protein, neutrophil oxidative metabolism, and lipid peroxidation in female dogs with pyometra associated with Escherichia coli

Authors

  • Mauren Picada Emanuelli
    • Department of Small Animal Clinic, Graduate Program in Veterinary MedicineFederal University of Santa Maria
  • Danieli Brolo Martins
    • Department of Small Animal Clinic, Graduate Program in Veterinary MedicineFederal University of Santa Maria
  • Patrícia Wolkmer
    • Department of Small Animal Clinic, Graduate Program in Veterinary MedicineFederal University of Santa Maria
  • Alfredo Quites Antoniazzi
    • Department of Large Animal Clinic, Graduate Program in Veterinary MedicineFederal University of Santa Maria
  • Tatiana Emanuelli
    • Department of ChemistryFederal University of Santa Maria
  • Agueda Castagna de Vargas
    • Department of Preventive Veterinary MedicineFederal University of Santa Maria
    • Department of Small Animal Clinic, Graduate Program in Veterinary MedicineFederal University of Santa Maria
Original Article

DOI: 10.1007/s00580-010-1097-z

Cite this article as:
Emanuelli, M.P., Martins, D.B., Wolkmer, P. et al. Comp Clin Pathol (2012) 21: 309. doi:10.1007/s00580-010-1097-z

Abstract

Pyometra is a common uterine disease found in adult female dogs during diestrus and it typically presents with several systemic abnormalities. The aim of this study was to evaluate complete blood counts (CBC), neutrophil oxidative metabolism, and lipid peroxidation in female dogs diagnosed with pyometra associated with Escherichia coli (E. coli). Twenty adult female dogs, from 2 to 14 years old, were allocated into two different groups. Animals placed in group 1 (G1) (n = 12) were diagnosed with pyometra associated with E. coli and animals placed in group 2 (G2) (n = 8) were clinically healthy female dogs. Red blood cell (RBC) count, packed cell volume, and hemoglobin were significantly lower in G1 than in G2. A significant increase in total plasma protein and white blood cell count (segmented neutrophils, band neutrophils, and monocytes) occurred in G1 when compared to G2. The neutrophil oxidative metabolism was also increased in G1, but lipid peroxidation showed no difference between the two groups. CBC results revealed a normocytic, normochromic anemia and leukocytosis characterized by a neutrophilia with a left shift in adult female dogs with pyometra associated with E. coli. Additionally, neutrophil oxidative metabolism showed an increase in its activity without producing lipid peroxidation, which possibly indicates that the anemia in canine pyometra is not related to oxidative stress.

Keywords

AnemiaLeukocytosisUterusBacteriumOxidative stressCanine

Copyright information

© Springer-Verlag London Limited 2010