Journal of Anesthesia

, Volume 4, Issue 1, pp 45–50

The cardiovascular effects of atracurium and it's metabolite

  • Kazuaki Fukushima
  • Tadashi Aoki
  • Kazuhiko Watanabe
  • Tesuo Satoh
  • Hideo Nagashima
Original Articles

DOI: 10.1007/s0054000040045

Cite this article as:
Fukushima, K., Aoki, T., Watanabe, K. et al. J Anesth (1990) 4: 45. doi:10.1007/s0054000040045

Abstract

The administration of atracurium to humans has been reported to produce little cardiovascular effects in clinical doses. The cardiovascular effect, histamine-releasing and catecholamine releasing effects of intravenous injection of atracurium 0.6 and 1.2 mg·kg−1 were studied in man, and also the cardiovascular and catecholamine releasing effects of laudanosine which is a metabolite of atracurium by Hofmann degeneration, were studied in dogs. The increase in human plasma concentration of histamine, hypotension and tachycardia were found with the dose of atracurium 1.2 mg·kg−1. The intravenous administration of laudanosine 10 μg·kg−1 to dogs produced minimal epinephrine, norepinephrine releases and cardiovascular changes.

Key words

Cardiovascular effectsatracuriumLaudanosinehistamine and catecholamine release

Copyright information

© Japanese Society of Anesthesiologists 1990

Authors and Affiliations

  • Kazuaki Fukushima
    • 1
  • Tadashi Aoki
    • 1
  • Kazuhiko Watanabe
    • 1
  • Tesuo Satoh
    • 1
  • Hideo Nagashima
    • 2
  1. 1.Department of AnesthesiologyNational Defense Medical CollegeTokorozawa, SaitamaJapan
  2. 2.Moiefiore Hospital & Medical CenterTokorozawaJapan