Journal of Anesthesia

, Volume 27, Issue 3, pp 380–384

The effects of single-dose intravenous dexmedetomidine on hyperbaric bupivacaine spinal anesthesia

  • Seung Hwan Jung
  • Soo Kyung Lee
  • Kyung Jee Lim
  • Eun Young Park
  • Mae Hwa Kang
  • Jung Min Lee
  • Jae Jun Lee
  • Sung Mi Hwang
  • Sung Jun Hong
Original Article

DOI: 10.1007/s00540-012-1541-0

Cite this article as:
Jung, S.H., Lee, S.K., Lim, K.J. et al. J Anesth (2013) 27: 380. doi:10.1007/s00540-012-1541-0

Abstract

Purpose

Dexmedetomidine, a selective α2-adrenoceptor agonist, has analgesic and sedative effects. The purpose of this study was to investigate the effects of small, single-dose intravenous dexmedetomidine administration after hyperbaric bupivacaine spinal anesthesia.

Methods

Sixty adult patients classified as American Society of Anesthesiologists physical status 1 or 2 and scheduled for lower extremity surgery under spinal anesthesia were studied. Patients were randomly assigned to one of three groups and administered hyperbaric intrathecal bupivacaine 12 mg. 5 min after spinal anesthesia, patients in groups 1, 2, and 3 received normal saline 10 ml, dexmedetomidine 0.25 μg/kg, and dexmedetomidine 0.5 μg/kg, respectively, over 10-min intravenous administration. The onset time, maximum block level, two-dermatome sensory regression time, duration of motor and sensory anesthesia, and side effects were assessed.

Results

The two-dermatome sensory regression time was significantly increased in groups 2 and 3. The duration of motor and sensory anesthesia was significantly increased in group 3. Onset time, maximum block level, level of sedation, and incidence of hypotension and treatment-needed bradycardia were no different among the groups.

Conclusion

Single-dose intravenous dexmedetomidine 0.25–0.5 μg/kg, administered 5 min after intrathecal injection of hyperbaric bupivacaine, improved the duration of spinal anesthesia without significant side effects. This method may be useful for increasing the duration of spinal anesthesia, even after intrathecal injection of local anesthetics.

Keywords

Bupivacaine Dexmedetomidine Spinal anesthesia 

Copyright information

© Japanese Society of Anesthesiologists 2013

Authors and Affiliations

  • Seung Hwan Jung
    • 1
  • Soo Kyung Lee
    • 2
  • Kyung Jee Lim
    • 2
  • Eun Young Park
    • 2
  • Mae Hwa Kang
    • 2
  • Jung Min Lee
    • 2
  • Jae Jun Lee
    • 2
  • Sung Mi Hwang
    • 2
  • Sung Jun Hong
    • 2
  1. 1.Department of Anesthesiology and Pain MedicineSeoul National University HospitalSeoulSouth Korea
  2. 2.Department of Anesthesiology and Pain MedicineHallym University Sacred Heart HospitalAnyangSouth Korea

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