Journal of Anesthesia

, Volume 25, Issue 2, pp 286–290

Use of rocuronium–sugammadex, an alternative to succinylcholine, as a muscle relaxant during electroconvulsive therapy

Authors

  • Hiroko Hoshi
    • Department of AnesthesiologyGunma University, School of Medicine
    • Department of AnesthesiologyGunma University, School of Medicine
  • Jiro Kamiyama
    • Department of AnesthesiologyGunma University, School of Medicine
  • Akiko Nishida
    • Department of AnesthesiologyGunma University, School of Medicine
  • Hiroyuki Saito
    • Department of AnesthesiologyGunma University, School of Medicine
  • Masaki Taguchi
    • Department of AnesthesiologyGunma University, School of Medicine
  • Shigeru Saito
    • Department of AnesthesiologyGunma University, School of Medicine
Clinical Report

DOI: 10.1007/s00540-011-1095-6

Cite this article as:
Hoshi, H., Kadoi, Y., Kamiyama, J. et al. J Anesth (2011) 25: 286. doi:10.1007/s00540-011-1095-6

Abstract

We compared the recovery time from neuromuscular blockade induced by rocuronium combined with sugammadex versus succinylcholine during electroconvulsive therapy (ECT). Anesthesia was induced using propofol, followed by succinylcholine (1 mg/kg) or rocuronium (0.6 mg/kg). Immediately after the seizure stopped, 16 mg/kg sugammadex was infused. Neuromuscular monitoring was performed and continued until recovery of the train-of-four ratio to 0.9. We compared the recovery time of T1 to 10 and 90% between groups. Patients were also assessed for clinical signs, such as time to first spontaneous breath from the administration of muscle relaxant and eye opening to verbal commands. Although recovery time of T1 to 10 and 90% in the rocuronium–sugammadex group was shorter than in the succinylcholine group, the difference was not statistically significant. Further, the seizure duration with succinylcholine (33 ± 8 s) was shorter than that with rocuronium–sugammadex (39 ± 4 s). In conclusion, this study demonstrates the potential benefit of use of rocuronium–sugammadex as an alternative to succinylcholine for muscle relaxation during ECT.

Keywords

Electroconvulsive therapyMuscle relaxantRocuroniumSugammadexSuccinylcholine

Copyright information

© Japanese Society of Anesthesiologists 2011