Journal of Anesthesia

, Volume 24, Issue 4, pp 537–543

Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later

  • Hance Clarke
  • Joseph Kay
  • Nicholas Mitsakakis
  • Joel Katz
Original Article

DOI: 10.1007/s00540-010-0960-z

Cite this article as:
Clarke, H., Kay, J., Mitsakakis, N. et al. J Anesth (2010) 24: 537. doi:10.1007/s00540-010-0960-z

Abstract

Purpose

Much remains unknown about the relationship between acute postoperative pain and the development of pathologic chronic postsurgical pain (CPSP). The purpose of this project was to identify the extent to which maximum pain scores on movement over the first two days after total hip arthroplasty predicted the presence of chronic pain 6 months later after controlling for potentially important covariates.

Methods

The sample comprised 82 of 114 patients who participated in a double-blinded randomized controlled trial in which all patients received acetaminophen 1 g p.o., celecoxib 400 mg p.o., and dexamethasone 8 mg i.v., 1–2 h preoperatively. In addition, patients received gabapentin (GBP) 600 mg (G2) or placebo (G1 and G3) 2 h prior to surgery [G1: placebo/placebo (n = 38); G2: GBP/placebo (n = 38); G3: placebo/GBP (n = 38)]. In the PACU, patients received gabapentin 600 mg (G3) or placebo (G1 and G2). Follow-up data from the 82 patients who were contacted by telephone 6 months postsurgery were used for the current study.

Results

Maximal movement-evoked pain intensity over the first two postoperative days (P = 0.38) failed to predict the presence of CPSP 6 months later after controlling for age (P = 0.09), treatment group (P = 0.91), and cumulative morphine consumption (P = 0.8) (multivariate logistic regression likelihood ratio test against the intercept only model P = 0.59).

Conclusion

Neither maximum movement-evoked acute pain, nor any other factor measured, predicted the presence of CPSP at 6 months. Further research is needed to identify risk factors for CPSP after total hip arthroplasty.

Keywords

Acute pain Chronic postsurgical pain Total hip arthroplasty 

Copyright information

© Japanese Society of Anesthesiologists 2010

Authors and Affiliations

  • Hance Clarke
    • 1
    • 2
    • 4
  • Joseph Kay
    • 2
    • 4
  • Nicholas Mitsakakis
    • 1
  • Joel Katz
    • 1
    • 2
    • 3
  1. 1.Department of Anesthesia and Pain ManagementToronto General Hospital, Acute Pain Research UnitTorontoCanada
  2. 2.Holland Orthopedic and Arthritic Centre, Sunnybrook Health Sciences CentreTorontoCanada
  3. 3.Department of Psychology and School of Kinesiology and Health ScienceYork UniversityTorontoCanada
  4. 4.Department of AnesthesiaUniversity of TorontoTorontoCanada