Fluid therapy with hydroxyethyl starch for massive blood loss during surgery
- Toshinari SuzukiAffiliated withDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University Email author
- , Hideki MiyaoAffiliated withDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University
- , Katsuo TeruiAffiliated withDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University
- , Kaoru KoyamaAffiliated withDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University
- , Michio ShiibashiAffiliated withInformation Technology Center, Saitama Medical University
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
This clinical trial reports the use of hydroxyethyl starch (HES70/0.55/4) at very high dosages during surgery. HES70/0.55/4 has the lowest molecular weight among all HES products, and thus may have the least side effects. This observational retrospective study clarified the effects of high-dose HES70/0.55/4 on coagulation and renal function up to 1 month after massive bleeding during surgery.
Of 20875 patients on our surgical database, 31 patients were identified who had lost more than 5000 ml of blood during surgery and had survived for more than 1 month. The fluid balance, and pre- and postoperative laboratory data were analyzed. Patients were assessed using acute kidney injury (AKI) criteria. AKI and non-AKI groups were compared regarding volume of HES70/0.55/4 infused and serum creatinine (Cr) levels before surgery and until 1 month after surgery.
The mean volumes of blood loss, total transfusions, HES70/0.55/4, and urine output during surgery were 8051 ml; 5765 ml; 3085 ml (54 ml/kg); and 1338 ml (2.7 ml/kg/h), respectively. Cr increased, and activated partial thromboplastin time, prothrombin time and international normalized ratio were prolonged postoperatively (0.77–0.9 mg/dl, 34–52 s, and 1.1–1.7, respectively). Of the 31 patients, 13 developed AKI, and 10 of the 13 had recovered at 1 month. Renal impairment due to HES70/0.55/4 was not evident, as shown by the finding that the HES70/0.55/4 amount infused in the AKI patients (53 ml/kg) did not differ from that in the nonAKI patients (55 ml/kg), and there was no relationship between the amount of HES infused and Cr changes.
High-dose HES70/0.55/4 could be safely used in massive bleeding during surgery. HES70/0.55/4 may affect coagulation, but renal impairment was not evident 1 month after surgery.
KeywordsHES70/0.55/4 Massive bleeding Adverse effects Renal complications Coagulation disorders
- Fluid therapy with hydroxyethyl starch for massive blood loss during surgery
Journal of Anesthesia
Volume 24, Issue 3 , pp 418-425
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Massive bleeding
- Adverse effects
- Renal complications
- Coagulation disorders
- Industry Sectors
- Author Affiliations
- 1. Department of Anesthesiology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan
- 2. Information Technology Center, Saitama Medical University, 38 Morohongo, Moroyama, Saitama, 350-0495, Japan