Journal of Anesthesia

, Volume 22, Issue 4, pp 443–445

Total intravenous anesthesia without muscle relaxant in a patient with amyotrophic lateral sclerosis

  • Dongchul Lee
  • Kyung Cheon Lee
  • Ji Young Kim
  • Yeon Soo Park
  • Young Jin Chang
Clinical Report

DOI: 10.1007/s00540-008-0655-x

Cite this article as:
Lee, D., Lee, K.C., Kim, J.Y. et al. J Anesth (2008) 22: 443. doi:10.1007/s00540-008-0655-x

Abstract

A 63-year-old woman with amyotrophic lateral sclerosis (ALS) was scheduled for open reduction and internal fixation of the right tibia. Total intravenous anesthesia using propofol and remifentanil without muscle relaxant was selected as the anesthetic method, in order to avoid the possible occurrence of ventilatory depression due to abnormal responses to muscle relaxants and exacerbation of the motor neuron disease. After standard and neuromuscular monitoring devices were applied, anesthesia was induced and maintained with target controlled infusion of propofol and remifentanil in the range of 2.5–5.0 μg·ml−1 and 2.5–5.0 ng·ml−1, respectively. To avoid delayed neuromuscular recovery, we did not use any muscle relaxant at all. Intubation was successful and there were no remarkable events during anesthesia, except for three brief hypotensive events; there was no exacerbation of ALS itself during or after the anesthesia. She was discharged on postoperative day 3, without any discomfort.

Key words

Amyotrophic lateral sclerosis Total intravenous anesthesia 

Copyright information

© Japanese Society of Anesthesiologists 2008

Authors and Affiliations

  • Dongchul Lee
    • 1
  • Kyung Cheon Lee
    • 1
  • Ji Young Kim
    • 1
  • Yeon Soo Park
    • 1
  • Young Jin Chang
    • 1
  1. 1.Department of Anesthesia and Pain MedicineGachon University of Medicine and Science, Gil Medical CenterIncheonSouth Korea