Journal of Gastroenterology

, Volume 35, Issue 11, pp 849–855

Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma

Authors

  • Hiroshi Nakamura
    • Fifth Department of Internal Medicine, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Ami-cho chuo, Ibaraki 300-0395, Japan
  • Naoki Ito
    • Department of Radiology, Tokyo Medical University, Tokyo, Japan
  • Fumio Kotake
    • Department of Radiology, Tokyo Medical University, Tokyo, Japan
  • Yuji Mizokami
    • Fifth Department of Internal Medicine, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Ami-cho chuo, Ibaraki 300-0395, Japan
  • Takeshi Matsuoka
    • Fifth Department of Internal Medicine, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Ami-cho chuo, Ibaraki 300-0395, Japan

DOI: 10.1007/s005350070022

Cite this article as:
Nakamura, H., Ito, N., Kotake, F. et al. J Gastroenterol (2000) 35: 849. doi:10.1007/s005350070022

Abstract:

The tumor-detecting capacity and clinical usefulness of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) were examined in patients with hepatocellular carcinoma. The tumor detection rate of SPIO-MRI (64.5%) was comparable to those of dynamic computed tomography (CT) and plain MRI, but lower than that for Gd dynamic MRI (93.5%; P < 0.01%). A combination of Gd dynamic MRI and SPIO-MRI improved the detection rate; further, the tumor stage with respect to tumor blood-flow pattern was predicted by combining plain MRI with SPIO-MRI. This combination procedure may also be useful for selecting therapeutic strategies.

Key words: superparamagnetic iron oxide (SPIO)hepatocellular carcinoma (HCC)magnetic resonance imaging (MRI)

Copyright information

© Springer-Verlag Tokyo 2000