Journal of Gastroenterology

, Volume 34, Issue 3, pp 376–377

Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis

Authors

  • Isao Sakaida
    • First Department of Internal Medicine, School of Medicine, Yamaguchi University, 1144 Kogushi, Ube 755-8505, Japan
  • Koichi Uchida
    • First Department of Internal Medicine, School of Medicine, Yamaguchi University, 1144 Kogushi, Ube 755-8505, Japan
  • Koji Hironaka
    • First Department of Internal Medicine, School of Medicine, Yamaguchi University, 1144 Kogushi, Ube 755-8505, Japan
  • Kiwamu Okita
    • First Department of Internal Medicine, School of Medicine, Yamaguchi University, 1144 Kogushi, Ube 755-8505, Japan
Short communication

DOI: 10.1007/s005350050277

Cite this article as:
Sakaida, I., Uchida, K., Hironaka, K. et al. J Gastroenterol (1999) 34: 376. doi:10.1007/s005350050277

Abstract:

The effects of a prolyl 4-hydroxylase inhibitor (HOE 077) on tissue inhibitor of metalloproteinase-1 (TIMP-1) and procollagen type I were examined in rat liver fibrosis. HOE 077 (200 ppm) prevented fibrosis by inhibiting the expression of liver type I procollagen and TIMP-1 mRNAs, with liver hydroxyroline content correlated with the reduction in activated stellate cells. HOE 077 prevents fibrosis by inhibiting proline hydroxylation and stellate cell activation, resulting in reduced expression of procollagen and TIMP-1 mRNAs.

Key words: prolyl 4-hydroxylase inhibitorprocollagentissue inhibitor of metalloproteinase-1 (TIMP-1)

Copyright information

© Springer-Verlag Tokyo 1999