Journal of Gastroenterology

, Volume 48, Issue 7, pp 822–829

A bioabsorbable polymer patch for the treatment of esophageal defect in a porcine model

  • Masayasu Aikawa
  • Mitsuo Miyazawa
  • Kojun Okamoto
  • Katsuya Okada
  • Naoe Akimoto
  • Hiroshi Sato
  • Isamu Koyama
  • Shigeki Yamaguchi
  • Yoshito Ikada
Original Article—Alimentary Tract

DOI: 10.1007/s00535-012-0716-7

Cite this article as:
Aikawa, M., Miyazawa, M., Okamoto, K. et al. J Gastroenterol (2013) 48: 822. doi:10.1007/s00535-012-0716-7

Abstract

Background

Although several materials have been used to replace the esophagus, none of the materials appears to be feasible for clinical use. Our group has developed a bioabsorbable polymer that can be used to repair the defects of stomach, small intestine, biliary tract, and veins. In this study, we implanted a bioabsorbable polymer patch (BAPP) into an esophageal defect and we investigated the clinical utility of BAPP and evaluated the process of esophageal regeneration.

Methods

Pigs (n = 9) underwent right thoracotomy under general anesthesia. A 4 × 2-cm oval-shaped portion of the esophageal wall was excised, and a BAPP was implanted at the excision site. Esophageal endoscopy was performed at 2 weeks after the implantation. At 4, 8, and 12 weeks after implantation, the whole esophagus was resected for gross and histological examinations of the graft sites.

Result

Esophageal endoscopy at 2 weeks revealed a tiny ulceration at the implantation site with no stenosis. At 4 weeks, the epithelium at the graft site was similar to that of the native esophagus, but it lacked a proper muscle layer. At 8 weeks, a rough muscle layer had developed. At 12 weeks, normal mucosa and a proper muscle layer similar to that of the native wall were confirmed.

Conclusion

BAPP repaired the defective esophageal wall without complications, and a neo esophageal wall identical to the native esophageal wall had formed by 12 weeks after implantation. Hence, this newly designed substitute has the potential for application as a novel treatment for defective esophagus.

Keywords

Bioabsorbable materialTissue engineeringEsophageal defectEsophageal reconstruction

Copyright information

© Springer Japan 2012

Authors and Affiliations

  • Masayasu Aikawa
    • 1
  • Mitsuo Miyazawa
    • 1
  • Kojun Okamoto
    • 1
  • Katsuya Okada
    • 1
  • Naoe Akimoto
    • 1
  • Hiroshi Sato
    • 1
  • Isamu Koyama
    • 1
  • Shigeki Yamaguchi
    • 1
  • Yoshito Ikada
    • 2
  1. 1.Department of Surgery, Gastrointestinal CenterSaitama Medical University, International Medical CenterHidakaJapan
  2. 2.Division of Life ScienceNara Medical UniversityNaraJapan