Journal of Gastroenterology

, Volume 48, Issue 1, pp 31-72

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Evidence-based clinical practice guidelines for Crohn’s disease, integrated with formal consensus of experts in Japan

  • Fumiaki UenoAffiliated withOfuna Chuo Hospital
  • , Toshiyuki MatsuiAffiliated withDepartment of Gastroenterology, Fukuoka University Chikushi Hospital
  • , Takayuki MatsumotoAffiliated withDivision of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine
  • , Katsuyoshi MatsuokaAffiliated withDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine
  • , Mamoru WatanabeAffiliated withDepartment of Gastroenterology and Hepatology, Tokyo Medical and Dental University
  • , Toshifumi HibiAffiliated withDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine Email author 
  • , On Behalf of the Guidelines Project Group of the Research Group of Intractable Inflammatory Bowel Disease subsidized by the Ministry of Health, Labour and Welfare of Japan and the Guidelines Committee of the Japanese Society of Gastroenterology


Crohn’s disease is a disorder of unknown etiology and complicated pathogenesis. A substantial amount of evidence has accumulated recently and has been applied to clinical practice. The present guidelines were developed based on recent evidence and the formal consensus of experts relevant to this disease. Here we provide an overview of these guidelines, as follows.
  • Target disease: Crohn’s disease

  • Users: Clinical practitioners in internal medicine, surgery, gastroenterology, and general practice

  • Purpose: To provide appropriate clinical indicators to practitioners

  • Scope of clinical indicators: Concept of Crohn’s disease, epidemiology, classifications, diagnosis, treatment, follow up, and special situations

  • Intervention: Diagnosis (interview, physical examination, clinical laboratory tests, imaging, and pathology) and treatment (lifestyle guidance, drug therapy, nutritional therapy, surgery, etc.)

  • Outcome assessment: Attenuation of symptoms, induction and maintenance of remission, imaging findings, quality of life (QOL), prevention of complications and harm of therapy

  • Methods for developing these guidelines: Described in the text

  • Basis of recommendations: Integration of evidence level and consensus of experts

  • Cost-benefit analysis: Not implemented

  • Evaluation of effectiveness: Yet to be confirmed

  • Status of guidelines: Updated version of the first Guidelines published in 2010

  • Publication sources: Printed publication available and electronic information in preparation

  • Patient information: Not available

  • Date of publication: October 2011

These guidelines were intended primarily to be used by practitioners in Japan, and the goal of these guidelines is to improve the outcomes of patients with Crohn’s disease.


Crohn’s disease Guidelines Practice guidelines Evidence Consensus