Journal of Gastroenterology

, Volume 47, Issue 9, pp 1036–1047

Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT

  • Tatsuo Inoue
  • Masatoshi Kudo
  • Mina Komuta
  • Sosuke Hayaishi
  • Taisuke Ueda
  • Masahiro Takita
  • Satoshi Kitai
  • Kinuyo Hatanaka
  • Norihisa Yada
  • Satoru Hagiwara
  • Hobyung Chung
  • Toshiharu Sakurai
  • Kazuomi Ueshima
  • Michiie Sakamoto
  • Osamu Maenishi
  • Tomoko Hyodo
  • Masahiro Okada
  • Seishi Kumano
  • Takamichi Murakami
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-012-0571-6

Cite this article as:
Inoue, T., Kudo, M., Komuta, M. et al. J Gastroenterol (2012) 47: 1036. doi:10.1007/s00535-012-0571-6

Abstract

Background

We aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate between HCCs and DNs.

Methods

Eighty-six nodules diagnosed as HCC or DNs were retrospectively investigated. Gd-EOB-DTPA-enhanced MRI and dynamic MDCT were compared with respect to their diagnostic ability for hypervascular HCCs and detection sensitivity for hypovascular tumors. The ability of hepatobiliary images of Gd-EOB-DTPA-enhanced MRI to discriminate between these nodules was assessed. We also calculated the EOB enhancement ratio of the tumors.

Results

For hypervascular HCCs, the diagnostic ability of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of MDCT for tumors less than 2 cm (p = 0.048). There was no difference in the detection of hypervascular HCCs between hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI (43/45: 96%) and dynamic MDCT (40/45: 89%), whereas the detection sensitivity of hypovascular tumors by Gd-EOB-DTPA-enhanced MRI was significantly higher than that by dynamic MDCT (39/41: 95% vs. 25/41: 61%, p = 0.001). EOB enhancement ratios were decreased in parallel with the degree of differentiation in DNs and HCCs, although there was no difference between DNs and hypovascular well-differentiated HCCs.

Conclusion

The diagnostic ability of Gd-EOB-DTPA-enhanced MRI for hypervascular HCCs less than 2 cm was significantly higher than that of MDCT. For hypovascular tumors, the detection sensitivity of hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of dynamic Gd-EOB-DTPA-enhanced MRI and dynamic MDCT. It was difficult to distinguish between DNs and hypovascular well-differentiated HCCs based on the EOB enhancement ratio.

Keywords

Gd-EOB-DTPA Hepatocellular carcinoma Dysplastic nodule 

Copyright information

© Springer 2012

Authors and Affiliations

  • Tatsuo Inoue
    • 1
  • Masatoshi Kudo
    • 1
  • Mina Komuta
    • 2
  • Sosuke Hayaishi
    • 1
  • Taisuke Ueda
    • 1
  • Masahiro Takita
    • 1
  • Satoshi Kitai
    • 1
  • Kinuyo Hatanaka
    • 1
  • Norihisa Yada
    • 1
  • Satoru Hagiwara
    • 1
  • Hobyung Chung
    • 1
  • Toshiharu Sakurai
    • 1
  • Kazuomi Ueshima
    • 1
  • Michiie Sakamoto
    • 2
  • Osamu Maenishi
    • 3
  • Tomoko Hyodo
    • 4
  • Masahiro Okada
    • 4
  • Seishi Kumano
    • 4
  • Takamichi Murakami
    • 4
  1. 1.Division of Gastroenterology and Hepatology, Department of Internal MedicineKinki University Faculty of MedicineOsaka-SayamaJapan
  2. 2.Department of PathologyKeio University Faculty of MedicineTokyoJapan
  3. 3.Department of PathologyKinki University Faculty of MedicineOsaka-SayamaJapan
  4. 4.Department of RadiologyKinki University Faculty of MedicineOsaka-SayamaJapan

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