, Volume 46, Issue 5, pp 712-713
Date: 24 Feb 2011

Proton pump inhibitors therapy for esophageal eosinophilia: simply following consensus guidelines

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We read with great interest the article by Abe et al. [1], in which the authors describe a series of 12 patients with esophageal eosinophilic infiltration (EEI, defined as ≥15 eo/HPF), of whom 8 had dysphagia or chest pain as the major complaint, 1 had gastroesophageal reflux disease (GERD) symptoms, and the remaining 3 were asymptomatic. Despite the limitations owing to the retrospective design of the study, clinical, endoscopic, and histological remission was documented in 3 out of 6 patients after reevaluation on proton pump inhibitors (PPI) therapy. Interestingly, one of these PPI responders was asymptomatic and EEI was incidentally found during annual follow-up for chronic gastritis. Similarly, a recent Korean study [2] has shown complete remission on PPI therapy in some patients with positive endoscopic and histological findings for eosinophilic esophagitis (EoE). EoE is still considered to be a rare condition in Asia. The first case dates from 2008 and was reported in an asympto ...

An answer to this letter to the editor is available at doi:10.1007/s00535-011-0389-7.