Journal of Gastroenterology

, Volume 46, Issue 2, pp 203–211

Characteristics of recurrence after curative resection for T1 colorectal cancer: Japanese multicenter study

  • Hirotoshi Kobayashi
  • Hidetaka Mochizuki
  • Takayuki Morita
  • Kenjiro Kotake
  • Tatsuo Teramoto
  • Shingo Kameoka
  • Yukio Saito
  • Keiichi Takahashi
  • Kazuo Hase
  • Masatoshi Oya
  • Koutarou Maeda
  • Takashi Hirai
  • Masao Kameyama
  • Kazuo Shirouzu
  • Kenichi Sugihara
Original Article—Alimentary Tract

DOI: 10.1007/s00535-010-0341-2

Cite this article as:
Kobayashi, H., Mochizuki, H., Morita, T. et al. J Gastroenterol (2011) 46: 203. doi:10.1007/s00535-010-0341-2
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Abstract

Background

Because the rate of recurrence after curative resection for T1 colorectal cancer is low, the characteristics of recurrence remain obscure. This multicenter study attempted to clarify the characteristics of recurrence after curative resection for T1 colorectal cancer.

Methods

We analyzed the associations between recurrence and various clinicopathological features in 798 patients who had undergone curative resection alone for T1 colorectal cancer at 14 hospitals between 1991 and 1996.

Results

The rate of lymph node metastasis (LNM) in patients with T1 colorectal cancer was 10.5% (84/798), and 18 (2.3%) of the 798 patients developed recurrence during the median follow-up of 7.8 years. The recurrence rates in patients with colon cancer with and without LNM were 3.6 and 1.3%, respectively (p = 0.19). These rates in patients with cancer of the rectum were 25.0 and 1.1% (p < 0.0001). Among various parameters, histological grade (p < 0.0001), location (p = 0.025), LNM (p < 0.0001), and venous invasion (p = 0.0013) were risk factors for recurrence. Among them, LNM (p = 0.0008) and histological grade (p = 0.041) were independent risk factors for recurrence after curative resection for T1 colorectal cancer. Time to recurrence was more likely to be shorter for patients with, than without nodal involvement. In patients with an unfavorable histological grade, all recurrences developed within 1 year.

Conclusions

The recurrence rate after curative resection for node-negative T1 colorectal cancer was very low. The effectiveness of surveillance to detect recurrence after curative resection for T1 colorectal cancer should be validated in further studies.

Keywords

Lymph node metastasisLymph node ratioVenous invasionHistological gradeRelapse

Copyright information

© Springer 2010

Authors and Affiliations

  • Hirotoshi Kobayashi
    • 1
  • Hidetaka Mochizuki
    • 2
  • Takayuki Morita
    • 3
  • Kenjiro Kotake
    • 4
  • Tatsuo Teramoto
    • 5
  • Shingo Kameoka
    • 6
  • Yukio Saito
    • 7
  • Keiichi Takahashi
    • 8
  • Kazuo Hase
    • 9
  • Masatoshi Oya
    • 10
  • Koutarou Maeda
    • 11
  • Takashi Hirai
    • 12
  • Masao Kameyama
    • 13
  • Kazuo Shirouzu
    • 14
  • Kenichi Sugihara
    • 1
  1. 1.Department of Surgical Oncology, Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of SurgeryNational Defense Medical CollegeTokorozawaJapan
  3. 3.Department of Surgery, School of MedicineHirosaki UniversityHirosakiJapan
  4. 4.Department of SurgeryTochigi Cancer CenterTochigiJapan
  5. 5.Division of General and Gastroenterological Surgery, Department of Surgery (Omori), School of MedicineToho UniversityTokyoJapan
  6. 6.Department of Surgery IITokyo Women’s Medical UniversityTokyoJapan
  7. 7.Department of SurgeryInternational Medical Center of JapanTokyoJapan
  8. 8.Department of SurgeryTokyo Metropolitan Komagome HospitalTokyoJapan
  9. 9.Department of SurgerySelf-Defense Forces Central HospitalTokyoJapan
  10. 10.Department of SurgeryCancer Institute HospitalTokyoJapan
  11. 11.Department of SurgeryFujita Health UniversityToyoakeJapan
  12. 12.Department of Gastroenterological SurgeryAichi Cancer Center HospitalNagoyaJapan
  13. 13.Department of SurgeryOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan
  14. 14.Department of SurgeryKurume University School of MedicineKurumeJapan