Journal of Gastroenterology

, Volume 46, Issue 3, pp 359–366

A novel transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma: a prospective randomized trial

Authors

    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Satoe Hamabe
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Issei Saeki
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Yohei Harima
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Yuhki Yamaguchi
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Koichi Uchida
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Shuji Terai
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
  • Isao Sakaida
    • Department of Gastroenterology and HepatologyYamaguchi University Graduate School of Medicine
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-010-0306-5

Cite this article as:
Yamasaki, T., Hamabe, S., Saeki, I. et al. J Gastroenterol (2011) 46: 359. doi:10.1007/s00535-010-0306-5

Abstract

Background

We designed a novel transcatheter arterial infusion chemotherapy (TAI) using iodized oil (lipiodol) and degradable starch microspheres (DSM) for hepatocellular carcinoma (HCC) patients. In this study, we investigated the efficacy of TAI using lipiodol and DSM in a prospective randomized trial.

Methods

We randomly divided 45 patients with HCC into 3 groups: TAI using lipiodol (lipiodol group, n = 15), TAI using DSM (DSM group, n = 15), and TAI using lipiodol and DSM (lipiodol + DSM group, n = 15). In the lipiodol group, a mixture of cisplatin and lipiodol was administered. In the DSM group, a mixture of cisplatin and DSM was administered. In the lipiodol + DSM group, a mixture of cisplatin and lipiodol was administered, followed by DSM.

Results

The response rates were 40% in the lipiodol group, 53.4% in the DSM group, and 80% in the lipiodol + DSM group, respectively. The response rate tended to improve in the lipiodol + DSM group (lipiodol group vs. lipiodol + DSM group, P = 0.07). The median progression-free survival time was 177 days in the lipiodol group, 287 days in the DSM group, and 377 days in the lipiodol + DSM group. The progression-free survival in the lipiodol + DSM group was significantly better than those in the DSM group (P = 0.020) and the lipiodol group (P = 0.035). There were no serious adverse effects among the 3 groups.

Conclusions

TAI using lipiodol and DSM was superior to TAI using lipiodol only and TAI using DSM only because of improvements in therapeutic effects and progression-free survival.

Keywords

Hepatocellular carcinomaTranscatheter arterial infusion chemotherapyIodized oilDegradable starch microspheresRandomized trial

Copyright information

© Springer 2010