Journal of Gastroenterology

, Volume 45, Issue 2, pp 234–243

Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan

Authors

    • Department of Medicine and Bioregulatory Science, Graduate School of Medical SciencesKyushu University
  • Hironobu Sasano
    • Department of PathologyTohoku University School of Medicine
  • Masao Tanaka
    • Department of Surgery and Oncology, Graduate School of Medical SciencesKyushu University
  • R. Yoshiyuki Osamura
    • Department of PathologyTokai University School of Medicine
  • Iwao Sasaki
    • Department of SurgeryTohoku University Graduate School of Medicine
  • Wataru Kimura
    • Course of Organ Functions and Controls, Department of Gastroenterological and General SurgeryYamagata University School of Medicine
  • Koji Takano
    • Department of Nephrology and EndocrinologyUniversity of Tokyo Faculty of Medicine
  • Takao Obara
    • Department of Endocrine SurgeryTokyo Women’s Medical University
  • Miyuki Ishibashi
    • Department of MedicineTakatsu General Hospital
  • Kazuwa Nakao
    • Division of Endocrinology and Metabolism, Department of Medicine and Clinical ScienceKyoto University Graduate School of Medicine
  • Ryuichiro Doi
    • Department of SurgeryKyoto University
  • Akira Shimatsu
    • Clinical Research InstituteNational Hospital Organization Kyoto Medical Center
  • Toshirou Nishida
    • Department of SurgeryOsaka University Graduate School of Medicine
  • Izumi Komoto
    • Department of SurgeryOsaka Saiseikai Noe Hospital
  • Yukio Hirata
    • Department of Clinical and Molecular EndocrinologyTokyo Medical and Dental University Graduate School
  • Kazuhiko Nakamura
    • Department of Medicine and Bioregulatory Science, Graduate School of Medical SciencesKyushu University
  • Hisato Igarashi
    • Department of Medicine and Bioregulatory Science, Graduate School of Medical SciencesKyushu University
  • Robert T. Jensen
    • Digestive Diseases Branch, National Institutes of Diabetes, Digestive and Kidney DiseasesNational Institutes of Health
  • Bertram Wiedenmann
    • Department of Hepatology and GastroenterologyUniversity Medicine Berlin
  • Masayuki Imamura
    • Department of SurgeryOsaka Saiseikai Noe Hospital
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-009-0194-8

Cite this article as:
Ito, T., Sasano, H., Tanaka, M. et al. J Gastroenterol (2010) 45: 234. doi:10.1007/s00535-009-0194-8

Abstract

Background

There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan.

Methods

We examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sampling method.

Results

A total of 2,845 individuals received treatment for PETs. Prevalence was estimated as 2.23/100,000 with an annual onset incidence of 1.01/100,000. Non-functioning tumor (NF)-PET constituted 47.4%, followed by insulinoma (38.2%) and gastrinoma (7.9%). Distant metastases were reported in 21% patients with NF-PETs and occurred more frequently as tumor size increased (>2 cm). Multiple endocrine neoplasia type 1 (MEN-1) was detected in 10% of PETs but only in 6.1% of NF-PETs. NF-PETs were detected incidentally by physical examination in 24% patients. In 2005, an estimated 4,406 patients received treatment for GI-NETs. Prevalence was estimated as 3.45/100,000, with an annual onset incidence of 2.10/100,000. The locations of GI-NETs varied: foregut, 30.4%; midgut, 9.6%; and hindgut, 60.0%. Distant metastases were observed in 6%. Lymph node metastases occurred more frequently as tumor size increased (>1 cm). The frequency of MEN-1 complications was 1%. Physical examination revealed GI-NETs in 44% patients. The frequency of symptomatic GI-NETs was 3.4%. Interestingly, 77.1% of patients with foregut GI-NETs had type A gastritis.

Conclusion

Our results show there are large differences in GEP-NETs between Japan and Western nations, primarily due to differences in the presence of MEN-1 in NF-PETs and the location, symptomatic status, and prevalence of malignancy in GI-NETs.

Keywords

Neuroendocrine tumorEndocrine pancreatic tumorGastrointestinal neuroendocrine tumorsNationwide surveyEpidemiology

Copyright information

© Springer 2010