Journal of Gastroenterology

, 44:1046

Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis

Authors

    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
  • Shino Ohno
    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
  • Tomoya Sakurada
    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
  • Hidehiko Takabayashi
    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
  • Mitsuko Kudo
    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
  • Shoki Ro
    • Central Research LaboratoriesTeikyo University Chiba Medical Center, Ichihara
  • Shingo Kato
    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
  • Koji Yakabi
    • Department of Gastroenterology and Hepatology, Saitama Medical CenterSaitama Medical University
Original Article—Alimentary Tract

DOI: 10.1007/s00535-009-0120-0

Cite this article as:
Kawashima, J., Ohno, S., Sakurada, T. et al. J Gastroenterol (2009) 44: 1046. doi:10.1007/s00535-009-0120-0

Abstract

Purpose

We attempted to clarify the significance of atrophic change of gastric mucosa for reduction of plasma ghrelin concentration irrespective of Helicobacter pylori (Hp) infection.

Methods

Plasma acylated (acyl-)ghrelin concentration in 220 subjects, both with and without atrophic gastritis, was measured with an enzyme immunoassay kit. The extent of atrophic change of gastric mucosa was assessed and graded endoscopically. Hp infection was determined by assay of the anti-Hp antibody with an ELISA assay kit.

Results

Plasma acyl-ghrelin concentration was significantly lower in the Hp positive than the Hp negative group, and Hp eradication significantly increased plasma acyl-ghrelin concentrations in Hp positive subjects. Plasma acyl-ghrelin was significantly lower in subjects with severely atrophic gastritis than in those with mild or moderate atrophic gastritis, irrespective of Hp infection or age group (<60 years old or ≧60 years old). In male subjects with a normal body mass index, plasma acyl-ghrelin concentrations in subjects with severely atrophic gastritis were significantly lower than those in subjects with mildly or moderately atrophic gastritis, suggesting that the results of the study are independent of emaciation or obesity. Logistic regression analysis showed that gastric atrophy is the key factor that modulates plasma acyl-ghrelin levels.

Conclusions

The results suggest that plasma acyl-ghrelin concentration decreases in accordance with the extent of atrophic change in gastric mucosa irrespective of Hp infection, indicating that the low plasma acyl-ghrelin level of subjects with Hp infection is mainly caused by the progress of atrophic changes in gastric mucosa.

Keywords

GhrelinHelicobacter pyloriEradicationAtrophic gastritis

Copyright information

© Springer 2009