Journal of Gastroenterology

, Volume 44, Issue 9, pp 976–982

Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease

  • Katsutoshi Tokushige
  • Etsuko Hashimoto
  • Haruka Noto
  • Satoru Yatsuji
  • Makiko Taniai
  • Nobuyuki Torii
  • Keiko Shiratori
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-009-0085-z

Cite this article as:
Tokushige, K., Hashimoto, E., Noto, H. et al. J Gastroenterol (2009) 44: 976. doi:10.1007/s00535-009-0085-z

Abstract

Purpose

Single nucleotide polymorphisms (SNPs) of the adiponectin gene have been reported to be associated with insulin resistance and the prevalence of type-2 diabetes. We investigated the SNPs of adiponectin in non-alcoholic fatty liver disease (NAFLD) patients.

Methods

One hundred nineteen patients histologically diagnosed as having NAFLD and 115 control subjects were examined. Adiponectin SNP sites were investigated at +45 of exon 2 and at +276 of intron 2; these sites have been thought to be associated with diabetes or insulin resistance.

Results

Regarding the +276 SNP, the frequency of G/G tended to be higher in NAFLD patients than in controls, but not significantly. Among females only, however, the G/G frequency was significantly higher in NAFLD patients. As for the +45 SNP, in the severe fibrosis group, the frequency of G/G homozygotes was significantly higher than that in the mild fibrosis group, and G/G homozygotes of the +45 SNP proved by multivariate analysis to be an independent factor in severe fibrosis. In NAFLD patients with adiponectin +45 G/G, homeostasis model assessment-insulin resistance was significantly higher than in NAFLD patients without adiponectin +45 G/G.

Conclusion

Adiponectin SNPs were found to be associated with the progression of liver fibrosis and insulin resistance, suggesting that adiponectin SNPs might play roles in the occurrence and progression of NAFLD.

Keywords

NAFLDAdiponectinSNPInsulin resistance

Copyright information

© Springer 2009

Authors and Affiliations

  • Katsutoshi Tokushige
    • 1
  • Etsuko Hashimoto
    • 1
  • Haruka Noto
    • 1
  • Satoru Yatsuji
    • 1
  • Makiko Taniai
    • 1
  • Nobuyuki Torii
    • 1
  • Keiko Shiratori
    • 1
  1. 1.Department of Medicine and GastroenterologyTokyo Women’s Medical UniversityShinjuku-kuJapan