Journal of Gastroenterology

, Volume 44, Issue 3, pp 167–172

Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease

Authors

  • Sei Kakinuma
    • Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical ScienceUniversity of Tokyo
    • JST, ERATONakauchi Stem Cell and Organ Regeneration Project
  • Hiromitsu Nakauchi
    • Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical ScienceUniversity of Tokyo
    • JST, ERATONakauchi Stem Cell and Organ Regeneration Project
  • Mamoru Watanabe
    • Department of Gastroenterology and HepatologyTokyo Medical and Dental University
Review

DOI: 10.1007/s00535-008-2297-z

Cite this article as:
Kakinuma, S., Nakauchi, H. & Watanabe, M. J Gastroenterol (2009) 44: 167. doi:10.1007/s00535-008-2297-z

Abstract

Allogeneic liver transplantation is still the only effective treatment available to patients with liver failure. However, because there is a serious shortage of liver donors, an alternative therapeutic approach is needed. Transplantation of mature hepatocytes has been evaluated in clinical trials, but the long-term efficacy remains unclear and the paucity of donor cells limits this strategy. Stem-cell transplantation is a more promising alternative approach. Several studies have provided information about the mechanism underlying the proliferation and differentiation of hepatic stem/progenitor cells. Moreover, in experimental models of liver disease, transplantation of hepatic stem/progenitor cells or hepatocyte-like cells derived from multipotent stem cells led to donor cell-mediated repopulation of the liver and improved survival rates. However, before stem-cell transplantation can be applied in the clinic to treat liver failure in humans, it will be necessary to overcome several difficulties associated with the technique.

Key words

hepatocyte transplantationhierarchysingle-cell based analysis
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Copyright information

© Springer 2009