Journal of Gastroenterology

, Volume 44, Supplement 19, pp 53–56

Cyclooxygenase-2 inhibitors in patients with high gastrointestinal risk: are we there yet?

  • Vincent Wai-Sun Wong
  • Francis Ka-Leung Chan
International Forum 1

DOI: 10.1007/s00535-008-2260-z

Cite this article as:
Wong, V.WS. & Chan, F.KL. J Gastroenterol (2009) 44(Suppl 19): 53. doi:10.1007/s00535-008-2260-z


Gastrointestinal complications from the use of nonsteroidal antiinflammatory drugs (NSAIDs) are common and costly. Cyclooxygenase (COX)-2 inhibitors cause fewer gastrointestinal events than nonselective NSAIDs but may still result in peptic ulcer complications in a significant proportion of high-risk patients. The risk can be further reduced by prescribing COX-2 inhibitors together with proton pump inhibitors. Small-bowel injury is also commonly seen in long-term users of COX-2 inhibitors. The potential cardiovascular side effects of most COX-2 inhibitors and NSAIDs pose great challenge to physicians. Further studies are required to optimize the treatment regimen in patients with high cardiovascular and gastrointestinal risk and to decide the best treatment options for patients with small- and large-bowel complications.

Key words

peptic ulcer proton pump inhibitors cyclooxygenase inhibitors capsule endoscopy cardiovascular diseases 

Copyright information

© Springer Japan 2009

Authors and Affiliations

  • Vincent Wai-Sun Wong
    • 1
  • Francis Ka-Leung Chan
    • 1
  1. 1.Department of Medicine and Therapeutics and Institute of Digestive DiseaseThe Chinese University of Hong KongShatinPeople’s Republic of China

Personalised recommendations