Journal of Gastroenterology

, Volume 42, Issue 2, pp 181–185

A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis

Authors

  • Yasuyuki Kojima
    • Department of SurgeryYokosuka Kyosai Hospital
  • Masatoshi Mogaki
    • Department of SurgeryYokosuka Kyosai Hospital
  • Ryo Takagawa
    • Department of SurgeryYokosuka Kyosai Hospital
  • Ikuko Ota
    • Department of SurgeryYokosuka Kyosai Hospital
  • Mitsutaka Sugita
    • Department of SurgeryYokosuka Kyosai Hospital
  • Shiho Natori
    • Department of SurgeryYokosuka Kyosai Hospital
  • Yohei Hamaguchi
    • Department of SurgeryYokosuka Kyosai Hospital
  • Haruki Kurosawa
    • Department of SurgeryYokosuka Kyosai Hospital
  • Tadao Fukushima
    • Department of SurgeryYokosuka Kyosai Hospital
  • Hidenobu Masui
    • Department of SurgeryYokosuka Kyosai Hospital
  • Shingo Fukazawa
    • Department of SurgeryYokosuka Kyosai Hospital
  • Shoji Yamanaka
    • Department of PathologyYokosuka Kyosai Hospital
  • Yukio Tsuura
    • Department of PathologyYokosuka Kyosai Hospital
  • Kaoru Nagahori
    • Department of SurgeryYokosuka Kyosai Hospital
Case report

DOI: 10.1007/s00535-006-1981-0

Cite this article as:
Kojima, Y., Mogaki, M., Takagawa, R. et al. J Gastroenterol (2007) 42: 181. doi:10.1007/s00535-006-1981-0

Abstract

Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.

Key words

lymphoepithelioma-like carcinomaUCEBV
Download to read the full article text

Copyright information

© Springer-Verlag Tokyo 2007