Journal of Gastroenterology

, Volume 40, Issue 11, pp 1024–1028

Development of reflux esophagitis following Helicobacter pylori eradication

  • Masahiro Kawanishi
Article

DOI: 10.1007/s00535-005-1685-x

Cite this article as:
Kawanishi, M. J Gastroenterol (2005) 40: 1024. doi:10.1007/s00535-005-1685-x

Abstract

Background

We aimed to determine the incidence and causative factors of reflux esophagitis following Helicobacter pylori eradication in Japanese patients.

Methods

In patients in whom reflux esophagitis could not be detected endoscopically, we conducted an annual follow-up observation in 326 H. pylori-cured patients, 199 H. pylori-positive patients, and 151 H. pylori-negative patients, to study the incidence and causative factors of reflux esophagitis.

Results

Development of reflux esophagitis was observed in 74 (22.7%) of the H. pylori-cured patients during a median follow-up period of 6.0 years, in 16 (8.0%) of the H. pylori-positive patients during a median follow-up period of 5.0 years, and in 29 (19.2%) of the H. pylori-negative patients during a median follow-up period of 5.4 years. The results, after correction for sex and age, showed that H. pylori-cured patients had a significantly higher risk of reflux esophagitis than H. pylori-positive patients (risk ratio, 2.43; P < 0.01), but their risk did not differ from that in the H. pylori-negative patients. It was also shown that hiatal hernia (risk ratio, 4.01; P < 0.01) and smoking history (risk ratio, 1.77; P < 0.05) were significant risk factors for the development of reflux esophagitis.

Conclusions

With regard to the development of reflux esophagitis following H. pylori eradiation therapy, we observed that the frequency was higher in H. pylori-cured patients than in H. pylori-positive patients, but the frequency in H. pylori-cured patients and H. pylori-negative patients was the same. We elucidated that hiatal hernia and smoking history are important risk factors for reflux esophagitis.

Key words

reflux esophagitisHelicobacter pylori eradicationhiatal herniacausative factors of reflux esophagitissmoking

Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Masahiro Kawanishi
    • 1
  1. 1.Department of Internal MedicineHiroshima Mitsubishi HospitalHiroshimaJapan